RED BLOOD-CELL FRAGMENTATION - IMPROVED DETECTION AND IDENTIFICATION OF CAUSES
RED BLOOD-CELL FRAGMENTATION - IMPROVED DETECTION AND IDENTIFICATION OF CAUSES
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DOI：
10.1093/ajcp/90.3.268
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发表时间：
1988-09-01
影响因子：
3.5
通讯作者：
BESSMAN, JD
中科院分区：
文献类型：
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作者：
BESSMAN, JD
对 2,350 名受试者的外周血涂片和红细胞大小分布直方图进行了检查，以寻找红细胞碎片的证据。为了区分大于或等于 10 碎片/1,000 个红细胞（异常）的受试者与正常受试者，血涂片检查的灵敏度为 0.83，特异性为 0.30，而直方图检查的灵敏度为 0.97，特异性为 0.87。异常碎片的最常见原因是细胞毒性化疗的恶性肿瘤和严重缺铁。在两名受试者中，异常的红细胞碎片模式是先前自动血细胞计数评估为正常的受试者中血影蛋白突变体的线索。数据表明两个结论：对于红细胞碎片的常规识别，红细胞体积直方图似乎比外周血涂片更准确；通过异常直方图可识别的无症状血影蛋白异常可能是一种相对常见的疾病。
The peripheral blood film and the red blood cell size distribution histogram were examined for evidence of red blood cell fragments in 2,350 subjects. To distinguish subjects with greater than or equal to 10 fragments/1,000 red blood cells (abnormal) from normal, examination of the blood film was 0.83 sensitive and 0.30 specific, whereas examination of the histogram was 0.97 sensitive and 0.87 specific. The most common causes of abnormal fragmentation were malignancy with cytotoxic chemotherapy and severe iron deficiency. In two subjects, an abnormal red blood cell fragmentation pattern was the clue to a spectrin mutant in subjects with an automated blood count previously evaluated as normal. The data suggest two conclusions: the red blood cell volume histogram appears more accurate than the peripheral blood film for routine identification of red blood cell fragments; and asymptomatic spectrin abnormality identifiable by abnormal histogram may be a relatively common disorder.