SARS-Cov-2 trajectory predictions and scenario simulations from a global perspective: a modelling study.

SARS-Cov-2 trajectory predictions and scenario simulations from a global perspective: a modelling study.
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全球视角下的 SARS-Cov-2 轨迹预测和情景模拟:建模研究

DOI:
10.1038/s41598-020-75332-x
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发表时间:
2020-10-27
期刊:
影响因子:
4.6
通讯作者:
Deng J
Deng J
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Yang T;Liu Y;Deng W;Zhao W;Deng J

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从武汉出现的冠状病毒SARS-CoV-2,中国已经发展成为一场全球性的疫情。在这里,我们将人类流动性和非药物干预(社会距离和疑似病例隔离)结合到SEIR传播模型中,以了解冠状病毒如何在全球环境中传播。通过将随机传播过程与各地区实际报告的确诊病例总数进行拟合,估计并绘制了各地区特定时变繁殖数、社会距离率、复工率和疑似病例隔离率的动态趋势。研究发现,武汉关停后,武汉的繁殖数量从2020年1月23日的6982只(95%可信区间2.558-14.668)大幅下降到2月7日的1.130只(95%可信区间0.289-3.279),从武汉关停到3月中旬,武汉在社会疏远和疑似病例隔离方面的干预水平高于中国平均水平和西方平均水平。以95%的可信区间预测了截至2020年10月10日的西方国家未来的疫情轨迹。通过情景模拟,我们发现了早期国际旅行禁令和严格干预策略的好处,以及非药物干预的意义。从全球角度来看,在成功开发疫苗之前,每个国家都必须控制输入病例的风险,并执行严格的非药物干预措施。
The coronavirus SARS-CoV-2 emerging from Wuhan, China has developed into a global epidemic. Here, we combine both human mobility and non-pharmaceutical interventions (social-distancing and suspected-cases isolation) into SEIR transmission model to understand how coronavirus transmits in a global environment. Dynamic trends of region-specific time-variant reproduction number, social-distancing rate, work-resumption rate, and suspected-cases isolation rate have been estimated and plotted for each region by fitting stochastic transmission processes to the real total confirmed cases reported of each region. We find after shutdown in Wuhan, the reproduction number in Wuhan greatly declined from 6·982 (95% CI 2·558–14·668) on January 23rd, 2020 to 1.130 (95% CI 0.289–3.279) on February 7th, 2020, and there was a higher intervention level in terms of social-distancing and suspected-cases isolation in Wuhan than the Chinese average and Western average, for the period from the shutdown in Wuhan to mid-March. Future epidemic trajectories of Western countries up to October 10th, 2020, have been predicted with 95% confidence intervals. Through the scenario simulation, we discover the benefits of earlier international travel ban and rigorous intervention strategies, and the significance of non-pharmaceutical interventions. From a global perspective, it is vital for each country to control the risks of imported cases, and execute rigorous non-pharmaceutical interventions before successful vaccination development.
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影响因子: 158.5
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