Within-subject variability of BOLD response dynamics
Within-subject variability of BOLD response dynamics
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DOI：
10.1016/s1053-8119(03)00177-0
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发表时间：
2003-07-01
期刊：
影响因子：
5.7
通讯作者：
von Cramon, DY
中科院分区：
文献类型：
--
作者：
Neumann, J;Lohmann, G;von Cramon, DY
在这篇论文中，我们研究了在一系列相隔几天的fMRI会话中获得的BOLD响应的动力学方面的受试者内变异性。估计并分析了描述试验平均时间过程的时间行为的五个不同参数，如达峰时间和发作时间，以及它们在九个阶段中的变异性。结果表明，可以发现估计参数的小方差，只要分析仅限于在所有个别会话中激活的体素。在所研究的参数中，达峰时间表现出最稳定的行为。这些结果是使用两种不同的分析方法获得的，即直接从试验平均时间过程估计参数和将试验平均时间过程拟合到假设的血流动力学响应函数。两种方法产生的结果相当。(C)2003 Elsevier Science（美国）。All rights reserved.
this paper we investigate the within-subject variability of dynamical aspects of the BOLD response obtained in a series of fMRI sessions several days apart. Five different parameters describing the temporal behavior of trial-averaged time courses, such as time-to-peak and time-to-onset, were estimated and analyzed with respect to their variability across nine sessions. Results show that small variances of the estimated parameters can be found, provided that the analysis is restricted to voxels activated in all individual sessions. Among the investigated parameters, time-to-peak shows the most stable behavior. These results were obtained using two different analysis methods, the estimation of the parameters directly from trial-averaged time courses and fitting trial-averaged time courses to an assumed hemodynamic response function. Both methods yield comparable results. (C) 2003 Elsevier Science (USA). All rights reserved.