Glucagon and plasma catecholamines during beta-receptor blockade in exercising man.
Glucagon and plasma catecholamines during beta-receptor blockade in exercising man.
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运动男子β受体阻断期间的胰高血糖素和血浆儿茶酚胺。
DOI：
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发表时间：
1976
影响因子：
3.3
通讯作者：
J. Hilsted
中科院分区：
文献类型：
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作者：
H. Galbo;J. Holst;N. Christensen;J. Hilsted
7名男性在心得安(P)的β-肾上腺素能阻断(P)、烟酸(N)的脂肪溶解阻断(N)或不用药(C)期间以60%的个体最大摄氧量跑到力竭。总作业时间(83+/-9(P)、122+/-8(N)、166+/-10(C)min、Mean和SE)差异有统计学意义。肾上腺素水平逐渐高于运动前水平(0.06+/-0.01 ng/ml)，力竭时P组浓度(2.15+/-0.41)高于N组(1.08+/-0.31)和C组(0.72+/-0.28)。去甲肾上腺素持续增加，而胰岛素减少。在最初的下降之后，胰高血糖素的浓度随着血糖的下降而逐渐升高，并且在耗竭时总是运动前的三倍。因此，β-肾上腺素能受体阻滞剂并没有减弱胰高血糖素的反应。当P实验中的阿尔法受体刺激加强时，这种反应也没有增加。在C实验期间，碳水化合物燃烧较小，血清中NEFA和甘油浓度较大。在力竭状态下，丙氨酸浓度从未升高。因此，无论是肾上腺素能受体的刺激，还是NEFA和丙氨酸浓度，都不是运动诱导的人胰高血糖素分泌的主要决定因素。提示在长时间的运动中，葡萄糖供应减少会增加胰升糖素和肾上腺素的分泌。
Seven men ran at 60% of individual maximal oxygen uptake to exhaustion during beta-adrenergic blockade with propranolol (P), during lipolytic blockade with nicotinic acid (N), or without drugs (C). The total work times (83 +/- 9 (P), 122 +/- 8 (N), 166 +/- 10 (C) min, mean and SE) differed significantly. Epinephrine rose progressively above preexercise levels (0.06 +/- 0.01 ng/ml); at exhaustion concentrations in P experiments (2.15 +/- 0.41) were larger than in N (1.08 +/- 0.31) and C (0.72 +/- 0.28) experiments. Norepinephrine increased consistently while insulin decreased. After an initial decrease glucagon concentrations increased progressively in parallel with declining plasma glucose and were at exhaustion always three times preexercise values. Thus beta-adrenergic blockade did not diminish the glucagon response. Nor was this response increased when alpha-receptor stimulation in P experiments was intensified. Carbohydrate combustion was smaller and NEFA and glycerol concentrations in serum larger during C experiments. Alanine concentrations were never raised at exhaustion. Accordingly, neither stimulation of adrenergic receptors nor NEFA and alanine concentrations are major determinants for the exercise-induced glucagon secretion in man. It is suggested that decreased glucose availability enhances the secretion of glucagon and epinephrine during prolonged exercise.