Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives.
Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives.
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DOI：
10.3389/fcimb.2017.00295
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发表时间：
2017
影响因子：
5.7
通讯作者：
Bachrach G
中科院分区：
文献类型：
--
作者：
Abed J;Maalouf N;Parhi L;Chaushu S;Mandelboim O;Bachrach G
结直肠腺癌（Colorectal adenocarcinoma，CRC）是一种常见的恶性肿瘤，死亡率高.有趣的是，发现CRC被口腔厌氧菌具核梭杆菌定殖，这加速了肿瘤进展并使免疫逃避成为可能。通过梭菌Fap 2 Gal-GalNAc凝集素识别肿瘤展示的Gal-GalNAc部分介导梭菌的CRC特异性定植。在这里，我们显示高Gal-GalNAc水平在其他腺癌，包括那些发现在胃，前列腺，卵巢，结肠，子宫，胰腺，乳腺，肺，食管。这一观察结果与最近在一些肿瘤中发现梭菌DNA的报道相吻合。考虑到梭菌的致瘤作用及其免疫逃避特性，我们认为消除梭菌可能会改善上述肿瘤的治疗结果。此外，由于梭菌似乎特异性地归巢于Gal-GalNAc展示肿瘤，因此它可能被工程化为用于治疗CRC和上述常见的致死性腺癌的平台。
Colorectal adenocarcinoma (CRC) is a common tumor with high mortality rates. Interestingly, CRC was found to be colonized by the oral anaerobic bacteria Fusobacterium nucleatum, which accelerates tumor progression and enables immune evasion. The CRC-specific colonization by fusobacteria is mediated through the recognition of tumor displayed Gal-GalNAc moieties by the fusobacterial Fap2 Gal-GalNAc lectin. Here, we show high Gal-GalNAc levels in additional adenocarcinomas including those found in the stomach, prostate, ovary, colon, uterus, pancreas, breast, lung, and esophagus. This observation coincides with recent reports that found fusobacterial DNA in some of these tumors. Given the tumorigenic role of fusobacteria and its immune evasion properties, we suggest that fusobacterial elimination might improve treatment outcome of the above tumors. Furthermore, as fusobacteria appears to specifically home-in to Gal-GalNAc—displaying tumors, it might be engineered as a platform for treating CRC and the above common, lethal, adenocarcinomas.