Angiotensin II signaling in vascular smooth muscle - New concepts
Angiotensin II signaling in vascular smooth muscle - New concepts
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DOI：
10.1161/01.hyp.29.1.366
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发表时间：
1997-01-01
期刊：
影响因子：
8.3
通讯作者：
Alexander, RW
中科院分区：
文献类型：
--
作者：
Griendling, KK;UshioFukai, M;Alexander, RW
血管紧张素II是一种多功能激素，通过血管紧张素II与ATI受体相互作用引发的一系列复杂的细胞内信号传导事件影响血管平滑肌细胞的收缩和生长。细胞对血管紧张素II的反应是多相的，包括在数秒内刺激磷脂酶C和Ca 2+动员;在数分钟内激活磷脂酶D、A（2）、蛋白激酶C和MAP激酶;以及在数小时的基因转录和NADH/NADPH氧化酶活性后刺激。血管紧张素II还激活许多细胞内酪氨酸激酶。在这方面，它与生长因子和细胞因子受体共享信号传导的某些方面，包括磷脂酶C-γ、src和ras的激活; she与grb 2的关联;以及Jak/STAT途径的刺激。负责这一独特系列事件的细胞事件可能涉及受体运动和信号结构域的产生。阐明这些途径对于我们理解AT（1）受体作为肾素-血管紧张素系统的最终效应物的功能是重要的。
Angiotensin II is a multifunctional hormone that affects both contraction and growth of vascular smooth muscle cells through a complex series of intracellular signaling events initiated by the interaction of angiotensin II with the ATI receptor. The cellular response to angiotensin II is multiphasic, involving stimulation within seconds of phospholipase C and Ca2+ mobilization; activation within minutes of phospholipase D, A(2), protein kinase C, and MAP kinase: and stimulation after a period of hours of gene transcription and NADH/NADPH oxidase activity. Angiotensin II also activates numerous intracellular tyrosine kinases. In this respect, it shares some aspects of signaling with growth factor and cytokine receptors, including activation of phospholipase C-gamma, src, and ras; association of she with grb2; and stimulation of the Jak/STAT pathway. The cellular events responsible for this unique series of events may involve receptor movement and the creation of a signaling domain. Elucidation of these pathways is important to our understanding of AT(1) receptor function as a final effector of the renin-angiotensin system.