Anti-inflammatory effects of H(2)S during acute bacterial infection: a review.
Anti-inflammatory effects of H(2)S during acute bacterial infection: a review.
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DOI：
10.1186/s12967-017-1206-8
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发表时间：
2017-05-10
影响因子：
7.4
通讯作者：
Zella D
中科院分区：
文献类型：
--
作者：
Benedetti F;Curreli S;Krishnan S;Davinelli S;Cocchi F;Scapagnini G;Gallo RC;Zella D
硫化氢 (H2S) 以前仅被认为是一种有毒的环境空气污染物，现在越来越多地被认为是一种重要的信号分子，能够调节许多人体组织中的多种细胞途径。最近的研究表明，H2S 是响应不同的细胞刺激而内源性产生的，并在控制许多生理反应中发挥不同的作用。 H2S 在炎症中的确切作用仍然很大程度上未知。特别是，由于 H2S 的潜在治疗用途，人们正在积极研究 H2S 在调节急性和慢性感染炎症反应中的作用。为了研究 H2S 作为细菌感染期间抗炎介质的作用，我们开发了支原体感染的原代细胞和细胞系的离体模型。我们的数据表明 H2S 对 NF-kB 和 Nrf-2 分子途径具有二分效应，分别受到抑制和刺激。
Hydrogen sulfide (H2S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human tissues. As demonstrated in recent studies, H2S is produced endogenously in response to different cellular stimuli and plays different roles in controlling a number of physiological responses. The precise role of H2S in inflammation is still largely unknown. In particular, the role of H2S in the regulation of the inflammatory response in acute and chronic infections is being actively investigated because of its potential therapeutic use. To study the effect of H2S as an anti-inflammatory mediator during bacterial infections, we developed an ex vivo model of primary cells and cell lines infected with Mycoplasma. Our data demonstrate a dichotomic effect of H2S on the NF-kB and Nrf-2 molecular pathways, which were inhibited and stimulated, respectively.