Aging and Lung Disease Clinical Impact and Cellular and Molecular Pathways
Aging and Lung Disease Clinical Impact and Cellular and Molecular Pathways
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DOI：
10.1513/annalsats.201508-484pl
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发表时间：
2015-12-01
影响因子：
8.3
通讯作者：
Eickelberg, Oliver
中科院分区：
文献类型：
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作者：
Rojas, Mauricio;Mora, Ana L.;Eickelberg, Oliver
随着全球老龄化人口预计快速增长，显然需要了解老龄化的复杂过程，以制定可能延长此类患者健康寿命的干预措施。衰老与多种慢性疾病的易感性增加有关，肺部病变也不例外。人们发现，特发性肺纤维化和慢性阻塞性肺病等肺部疾病的患病率随着年龄的增长而显着增加。 2014年10月，匹兹堡大学肺科、过敏科和重症监护科与路德维希马克西米利安大学综合肺病学中心、肺生物与疾病研究所和德国慕尼黑亥姆霍兹中心共同主办了匹兹堡-慕尼黑肺科会议，重点关注衰老和肺部疾病。会议的目的是传播衰老机制的新概念，这些概念对老年人群中常见的肺部疾病的肺部生理学和发病机制产生影响。会议包括 28 场关于不同主题的演讲，本报告对此进行了总结。参与者确定了未来基础和转化研究的优先事项，这些研究将有助于确定与年龄相关的肺部疾病发病机制有关的分子见解，并设计针对这些肺部疾病的治疗干预措施。
With the expected rapid growth of the aging population worldwide, there is a clear need to understand the complex process of aging to develop interventions that might extend the health span in this group of patients. Aging is associated with increased susceptibility to a variety of chronic diseases, and lung pathologies are no exception. The prevalence of lung diseases such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease has been found to increase considerably with age. In October 2014, the Division of Pulmonary, Allergy, and Critical Care of the University of Pittsburgh cohosted the Pittsburgh-Munich Lung Conference focused in aging and lung disease with the Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Ludwig-Maximilians University and Helmholtz Zentrum Munich Germany. The purpose of the conference was to disseminate novel concepts in aging mechanisms that have an impact in lung physiology and pathogenesis of pulmonary diseases that commonly occur in older populations. The conference included 28 presentations on diverse topics, which are summarized in this report. The participants identified priorities for future basic and translational investigations that will assist in the identification of molecular insights involved in the pathogenesis of age-related pulmonary diseases and the design of therapeutic interventions for these lung conditions.