Association between ambient air pollution and breast cancer risk: The multiethnic cohort study
Association between ambient air pollution and breast cancer risk: The multiethnic cohort study
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DOI：
10.1002/ijc.32308
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发表时间：
2020-02-01
影响因子：
6.4
通讯作者：
Wu, Anna H.
中科院分区：
文献类型：
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作者：
Cheng, Iona;Tseng, Chiuchen;Wu, Anna H.
以前的研究使用不同的暴露方法来评估主要是白人的空气污染和乳腺癌风险，但没有得出结论。通过克里格法（NOx、NO2、PM10、PM2.5）、土地利用回归法（LUR、NOx、NO2）和加州线源扩散模型（CALINE 4、NOx、PM2.5）对多种族队列中的57，589名女性的颗粒物和氮氧化物的空气污染物暴露进行了估计，这些女性从招募（1993-1996）到2010年主要居住在洛杉矶县。考克斯比例风险模型被用来检查随时间变化的空气污染和乳腺癌发病率之间的关联调整混杂因素。按种族/民族和与主要道路的距离进行分层分析。在所有女性中，乳腺癌风险与克立格法和LUR法测定的NOx（每十亿分之50 [ppb]）和NO2（每20 ppb）以及克立格法测定的PM2.5和PM10（每10 μ g/m（3））呈正相关，但不显著。然而，在居住在主要道路500米范围内的妇女中，观察到氮氧化物的风险显著增加（风险比[HR] = 1.35，95%置信区间[95% CI]：1.02-1.79），NO2（HR = 1.44，95% CI：1.04-1.99），PM10（HR = 1.29，95% CI：1.07-1.55）和PM2.5（HR = 1.85，95% CI：1.15-2.99），通过LUR测定NOx（HR = 1.21，95% CI：1.01-1.45）和NO2（HR = 1.26，95% CI：1.00-1.59）。未观察到与CALINE评估的暴露量的总体相关性4。亚组分析表明，非裔美国人和日裔美国人之间的NOx和NO2的关联更强。有必要对多种族人群进行进一步研究，以确认空气污染，特别是近道路暴露对乳腺癌风险的影响。
Previous studies using different exposure methods to assess air pollution and breast cancer risk among primarily whites have been inconclusive. Air pollutant exposures of particulate matter and oxides of nitrogen were estimated by kriging (NOx, NO2, PM10, PM2.5), land use regression (LUR, NOx, NO2) and California Line Source Dispersion model (CALINE4, NOx, PM2.5) for 57,589 females from the Multiethnic Cohort, residing largely in Los Angeles County from recruitment (1993-1996) through 2010. Cox proportional hazards models were used to examine the associations between time-varying air pollution and breast cancer incidence adjusting for confounding factors. Stratified analyses were conducted by race/ethnicity and distance to major roads. Among all women, breast cancer risk was positively but not significantly associated with NOx (per 50 parts per billion [ppb]) and NO2 (per 20 ppb) determined by kriging and LUR and with PM2.5 and PM10 (per 10 mu g/m(3)) determined by kriging. However, among women who lived within 500 m of major roads, significantly increased risks were observed with NOx (hazard ratio [HR] = 1.35, 95% confidence interval [95% CI]: 1.02-1.79), NO2 (HR = 1.44, 95% CI: 1.04-1.99), PM10 (HR = 1.29, 95% CI: 1.07-1.55) and PM2.5 (HR = 1.85, 95% CI: 1.15-2.99) determined by kriging and NOx (HR = 1.21, 95% CI:1.01-1.45) and NO2 (HR = 1.26, 95% CI: 1.00-1.59) determined by LUR. No overall associations were observed with exposures assessed by CALINE4. Subgroup analyses suggested stronger associations of NOx and NO2 among African Americans and Japanese Americans. Further studies of multiethnic populations to confirm the effects of air pollution, particularly near-roadway exposures, on the risk of breast cancer is warranted.