New bioresorbable pin for the reduction of small bony fragments: Design, mechanical properties and in vitro degradation
New bioresorbable pin for the reduction of small bony fragments: Design, mechanical properties and in vitro degradation
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DOI：
10.1016/0142-9612(95)00327-4
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发表时间：
1996-08-01
期刊：
影响因子：
14
通讯作者：
Scholz, C
中科院分区：
文献类型：
--
作者：
Claes, LE;Ignatius, AA;Scholz, C
描述了一种用于小骨碎片复位的新型可吸收骨针的设计、材料特性和体内降解特性。Polypin（R）由70：30聚（L，DL-丙交酯）制成，通过三点弯曲试验测得的初始弯曲强度为155-163 MPa。环氧乙烷（EO）和伽马灭菌对其初始机械性能没有实质性影响。然而，523，000至600，000的初始分子量（M（w））在γ-灭菌后降低了60-75%。在37 ℃生理盐水溶液中孵育EO灭菌的骨针在18个月时完全丧失弯曲强度。在70摄氏度的加速测试导致仅96小时后强度完全丧失。在70 ℃下，伽马灭菌针的降解速度比EO灭菌针快约30%。室温下储存46个月，抗弯强度和分子量不受影响。Polypin（R）相对缓慢的强度损失率可能将可吸收器械的应用扩展到缓慢愈合的骨折。新的骨针设计允许应用轻度骨折块间加压，从而降低骨针松动的风险，并提供X线标记。(C)1996年爱思唯尔科学有限公司
The design, material properties, and in vivo degradation characteristics of a new resorbable pin for the reductions of small bony fragments are described. The Polypin(R), made of 70:30 poly(L, DL-lactide), had an initial bending strength of 155-163 MPa, as measured by a three-point bending test. Ethylene oxide (EO)- and gamma-sterilization did not substantially affect its initial mechanical properties. The initial molecular weight (M(w)) of 523,000 to 600,000, however, decreased 60-75% after gamma-sterilization. Incubation of the EO-sterilized pins in 37 degrees C saline solution produced a complete loss of bending strength at 18 months. An accelerated test at 70 degrees C led to a complete loss of strength after only 96 h. Degradation of the gamma-sterilized pin at 70 degrees C was about 30% faster than that of the EO-sterilized pin. Bending strength and molecular weight were unaffected by storage at room temperature for 46 months. The relatively slow strength loss rate of the Polypin(R) potentially extends the application of resorbable devices to slow-healing fractures. The new pin design allows application of light interfragmentary compression, thus reducing the risk of pin loosening, and an X-ray marker is provided. (C) 1996 Elsevier Science Limited