Facile synthesis of magnetic graphene and carbon nanotube composites as a novel matrix and adsorbent for enrichment and detection of small molecules by MALDI-TOF MS
Facile synthesis of magnetic graphene and carbon nanotube composites as a novel matrix and adsorbent for enrichment and detection of small molecules by MALDI-TOF MS
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DOI：
10.1039/c2jm34745h
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发表时间：
2012-09
影响因子：
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通讯作者：
C. Shi;Jiaoran Meng;Chunhui Deng
中科院分区：
文献类型：
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作者：
C. Shi;Jiaoran Meng;Chunhui Deng
在这项工作中，第一次，我们合成了磁性石墨烯和碳纳米管（石墨烯/CNT）复合材料，通过一个简单的溶剂热合成的磁铁矿颗粒在碳纳米管和石墨烯的存在下。磁性石墨烯/碳纳米管复合材料具有独特的结构，碳纳米管表面包覆有磁性颗粒，并在石墨烯片上存款，不仅具有很强的磁响应性，而且能有效地抑制石墨烯和碳纳米管的自聚集。通过使用它们的磁性分离性和大的表面积访问的客体分子，这种新型的复合材料已成功地用作基质和吸附剂的分析和富集的小分子化合物，使用基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）。结果表明，石墨烯/碳纳米管复合材料具有灵敏度高、解吸/电离过程简单、分析物解吸/电离效率高、芳香族分析物峰强度高等优点，这是由于石墨烯/碳纳米管具有π共轭网络结构，表面高度暴露的缘故。此外，它们表现出非常高的耐盐性，这使它们成为应用于分析和富集复杂介质中存在的小分子（如尿液样品）的良好候选物。
In this work, for the first time, we synthesized magnetic graphene and carbon nanotube (graphene/CNT) composites via a simple solvothermal synthesis of magnetite particles in the presence of CNTs and graphene. The magnetic graphene/CNT composites possess a unique structure in which CNTs are coated by magnetite particles and deposit on graphene sheets, which not only provides strong magnetic responsiveness for separation, but also prevents the self-aggregation of graphene and CNTs. By using their magnetic separability and large surface areas accessible for guest molecules, this novel composite has been successfully employed as a matrix and adsorbent for the analysis and enrichment of small molecule compounds using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). It is found that the graphene/CNT composites have several advantages such as higher sensitivity, facile desorption/ionization process, higher efficiency in analyte desorption/ionization and higher peak intensities for aromatic analytes, which are attributed to the distinct structure of magnetic graphene/CNTs comprised of π-conjugated networks with a highly exposed surface. Additionally, they exhibited very high salt tolerance, which makes them a good candidate for application in analysis and enrichment of small molecules present in complex media, such as urine samples.