Effect of β-Adrenergic Blockade on Resting and Stimulated Fat Mobilization
Effect of β-Adrenergic Blockade on Resting and Stimulated Fat Mobilization
复制标题
β-肾上腺素能阻断对静息和刺激脂肪动员的影响
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
C. J. Pattee
中科院分区：
文献类型：
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作者：
E. Pinter;C. J. Pattee
ABSTRACT Some metabolic effects of an acute β-adrenergic receptor blockade were studied in 34 healthy subjects. Plasma free fatty acid (FFA) and blood glucose levels were determined in all, and kinetic data of plasma FFA were obtained in several of these individuals. β-Adrenergic receptor blockade was induced by intravenous propranolol [l-isopropylamino-3-(l-naphthyloxy)-2-propanol hydrochloride] infusion (0.3 mg/kg/15 min). The influence of propranolol on fat mobilization was studied at metabolic rest and during both exogenous (adrenergic) and endogenous (mixed) stimulation of adipokinesis (intravenous infusion of 0.5 μg/kg/15 min of epinephrine and starvation >55 hr, respectively). At metabolic rest propranolol caused a slight drop in plasma FFA levels, due to a transient decrease in FFA production rate and an equally nonsignificant rise in the blood glucose concentrations. The adipokinetic effectiveness of the intravenous epinephrine infusion, on the other hand, was markedly suppressed by the prior adm...
