Overlap time-gating approach for improving time-domain diffuse fluorescence tomography based on the IRF-calibrated Born normalization.
Overlap time-gating approach for improving time-domain diffuse fluorescence tomography based on the IRF-calibrated Born normalization.
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DOI：
10.1364/ol.38.001841
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发表时间：
2013-06
期刊：
影响因子：
3.6
通讯作者：
Jiao Li;Xi Yi;Xin Wang;Yiming Lu;Limin Zhang;Huijuan Zhao;F. Gao
中科院分区：
文献类型：
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作者：
Jiao Li;Xi Yi;Xin Wang;Yiming Lu;Limin Zhang;Huijuan Zhao;F. Gao
使用全时间分辨（TR）数据的扩散荧光层析成像（DFT）方法已被证明可以大大提高重建图像的空间分辨率和定量精度。然而，这些方法通常遭受低的实际可行性，因为系统的脉冲响应函数（IRF）的影响和所使用的数据的时间分辨率和所需的信噪比（SNR）之间的权衡。我们提出了一个完整的TR方法，结合了一个IRF校准的完整的TR玻恩归一化和一个延迟时间门方案，以达到高信噪比，而不牺牲TR的信息内容。通过体模实验的全TR数据验证了该方法在空间分辨率和重建保真度方面优于传统的DFT方法。
Diffuse fluorescence tomography (DFT) methods using the full time-resolved (TR) data have been demonstrated to substantially improve the spatial resolution and quantitative accuracy of reconstructed images. However, these methods usually suffer from low practical feasibility because of the influence of the system impulse response function (IRF) and the trade-off between the used data time-resolution and the required signal-to-noise ratio (SNR). We present a full TR approach that combines an IRF-calibrated full TR Born normalization and an overlap-delaying time-gate scheme for attaining high SNR without sacrificing the TR information content. The approach is validated with full TR data from phantom experiments for its better performances in the spatial resolution and reconstruction fidelity compared to the traditional DFT methods.