Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans
Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans
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DOI：
10.1093/oxfordjournals.aje.a009074
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发表时间：
1997-06-15
影响因子：
5
通讯作者：
Katan, MB
中科院分区：
文献类型：
--
作者：
Zock, PL;Mensink, RP;Katan, MB
血清胆固醇酯的脂肪酸组成被用作脂肪酸摄入的定性生物标志物，但定量数据很少。在1987年至1992年期间，作者在四项对照试验中向232名健康的荷兰志愿者喂食各种脂肪酸，并测量了参与者胆固醇酯中脂肪酸的比例。每10%的能量作为亚油酸（18：2）喂养，使胆固醇酯中亚油酸的比例提高9.3 g/100 g脂肪酸（标准差（SD）3.1）。对于油酸（顺式-18：1），该数值为6.5 g/100 g（SD 1.7）;对于反式脂肪酸（反式-18：1），该数值为1.1（SD 0.5）;对于硬脂酸（18：0），该数值为1.0（SD 0.4）;对于棕榈酸（16：0），该数值为1.7（SD 0.5）;对于肉豆蔻酸（14：0），该数值为2.1（SD 0.7）;对于饱和脂肪酸混合物（12：0、14：0和16：0），该数值为2.2 g/100 g（SD 1.0）。响应的变异系数相当恒定，表明这些脂肪酸中的每一种的摄入量变化可以以类似的精度进行监测。这些数据可用于估计涉及单一膳食脂肪酸交换的实验研究中的依从性程度。胆固醇酯中的大多数脂肪酸也可用于观察性研究，以估计摄入量的差异。然而，由于自由生活的个人之间和人口之间的脂肪酸摄入量的多重同时差异，这些数据不能提供关于脂肪酸绝对摄入量的信息。
The fatty acid composition of serum cholesteryl esters is used as a qualitative biomarker of fatty acid intake, but quantitative data are scarce. Between 1987 and 1992, the authors fed various fatty acids in four controlled trials to 232 healthy Dutch volunteers and measured the proportion of fatty acids in participants' cholesteryl esters. Each 10% of energy fed as linoleic acid (18:2) raised the proportion of linoleic acid in cholesteryl esters by 9.3 g per 100 g of fatty acids (standard deviation (SD) 3.1). For oleic acid (cis-18:1), this figure was 6.5 g/100 g (SD 1.7); for trans fatty acids (trans-18:1), it was 1.1 (SD 0.5); for stearic acid (18:0), 1.0 (SD 0.4); for palmitic acid (16:0), 1.7 (SD 0.5); for myristic acid (14:0), 2.1 (SD 0.7); and for a mixture of saturated fatty acids (12:0, 14:0, and 16:0), it was 2.2 g/100 g (SD 1.0). The coefficient of variation of the responses was fairly constant, indicating that changes in intake for each of these fatty acids can be monitored with similar precision. These data can be used to estimate the degree of compliance in experimental studies involving exchanges of single dietary fatty acids. Most fatty acids in cholesteryl esters may also be used in observational studies to estimate differences in intake. However, because of multiple simultaneous differences in fatty acid intake between free-living individuals and between populations, such data cannot provide information on absolute intake of fatty acids.