Tibiofemoral Centroid Velocity Correlates More Consistently with Cartilage Damage Than Does Contact Path Length in Two Ovine Models of Stifle Injury
Tibiofemoral Centroid Velocity Correlates More Consistently with Cartilage Damage Than Does Contact Path Length in Two Ovine Models of Stifle Injury
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DOI：
10.1002/jor.22429
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发表时间：
2013-11-01
影响因子：
2.8
通讯作者：
Frank, Cyril B.
中科院分区：
文献类型：
--
作者：
Beveridge, Jillian E.;Heard, Bryan J.;Frank, Cyril B.
前十字韧带(ACL)断裂和/或半月板损伤是创伤后骨关节炎的已知危险因素。我们测试了这样一种假设，即日益异常的胫股质心路径长度和速度将与受伤绵羊软骨损伤的严重程度相关。6只绵羊接受了前交叉韧带/内侧副韧带联合切断(ACL/MCLx)，5只完全外侧半月板切除(Mx)，4只假关节切开术(Sham)。采用加权质心法测定站立时胫股软骨接触路径长度和相对运动速度。解剖时对软骨形态进行分级。韧带切断显著延长了平台质心路径长度和速度，而降低了髁突路径和速度。在内侧间隔室，平台和股动脉血流速度的差值(相对质心速度)比基线值增加了10倍。Mx侧方间隔区路径的减少与ACL/MCLx路径显著不同，但与基线或Sham值无关。重要的是，在任何一种损伤模型中，只有质心速度与软骨损伤一致相关，这表明虽然路径长度对于检测关节运动包络的变化很有价值，但它可能会平均出相对运动速率中有意义的峰值，这些峰值与这些模型中可能损害关节软骨的机制更密切相关。(C)2013年骨科研究会。由Wiley期刊公司出版，J Orthop Res 31：1745-1756,2013
Anterior cruciate ligament (ACL) rupture and/or meniscal injury are known risk factors for post-traumatic osteoarthritis. We tested the hypothesis that increasingly abnormal tibiofemoral centroid path lengths and velocities would correlate with the severity of cartilage damage in injured sheep. Six sheep underwent combined ACL/medial collateral ligament transection (ACL/MCLx), five complete lateral meniscectomy (Mx), and four sham arthrotomy (Sham). Weighted centroids were used to estimate in vivo tibiofemoral cartilage contact path length during stance and the velocity of relative motion. Cartilage morphology was graded at dissection. Ligament transection significantly elongated plateau centroid path lengths and velocities, whereas condyle paths and velocities were reduced. Differences between plateau and femoral velocities (relative centroid velocity) were increased up to 10-fold over baseline values in the medial compartment. Reductions in Mx lateral compartment paths were significantly different from ACL/MCLx paths, but not relative to baseline or Sham values. Importantly, only centroid velocities consistently correlated with cartilage damage in either injury model, suggesting that while path length is valuable in detecting changes in the envelope of joint motion, it may average out meaningful peaks in the rate of relative motion that more closely relate to the mechanisms that might be damaging articular cartilage in these models. (c) 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1745-1756, 2013