Pattern of abnormal Pap smears in developing countries: a report from a large referral hospital in Saudi Arabia using the revised 2001 Bethesda System.
Pattern of abnormal Pap smears in developing countries: a report from a large referral hospital in Saudi Arabia using the revised 2001 Bethesda System.
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DOI：
10.5144/0256-4947.2007.268
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发表时间：
2007-07
影响因子：
1.6
通讯作者：
Abdullah LS
中科院分区：
文献类型：
--
作者：
Abdullah LS
描述发展中国家使用经修订的Bethesda子宫颈抹片检查系统的异常子宫颈抹片检查频率和模式的报告很少。我们使用修订后的系统研究了沙特阿拉伯西部地区沙特女性子宫颈上皮内病变和癌的检测模式。1998年1月1日至2005年8月31日期间在吉达阿卜杜勒阿齐兹国王医疗城病理部门报告的所有子宫颈涂片检查都根据修订后的系统重新分类，并确定了年龄范围。在5590份足够的涂片中，261例（5%）被诊断为异常，并进一步分类为未确定意义的非典型鳞状细胞（ASC-US）（103例，40%）、高级别非典型鳞状细胞（6例，2%）、低级别鳞状上皮内病变（LSIL）（56例，22%）、高级别鳞状上皮内病变（HSIL）（31例，12%）、腺体细胞异常（30例，11%）和浸润性鳞状细胞癌（21例，9%）。ASC-US/SIL比值为1.9%。浸润性腺癌占14例（4%），年龄范围与浸润性鳞状细胞癌相似。尽管该研究显示，与国际上发表的其他研究相比，宫颈上皮细胞异常的发生率较低，年龄范围较广，但结果强调需要一个组织良好的宫颈筛查计划，并辅以更大规模的全国宫颈异常模式研究。本研究提供的信息将鼓励在发展中国家使用子宫颈抹片检查作为宫颈癌的筛查方法。
Reports describing the frequency and pattern of abnormal Pap smears in developing countries using the revised Bethesda system for Pap smear are few. We studied the pattern of cervical intraepithelial lesions and carcinoma detected in Pap smears of Saudi females in the western region of Saudi Arabia using the revised system. All cervical Pap smears reported in the Department of Pathology of King Abdulaziz Medical City, Jeddah, from 1 January 1998 to 31 August 2005 were reclassified according to the revised system with age ranges identified. Of 5590 sufficient smears, 261 (5%) were identified as abnormal and were further classified as atypical squamous cells of undetermined significance (ASC-US) (103 cases, 40%), atypical squamous cells of high grade (6 cases, 2%), low-grade squamous intraepithelial lesions (LSIL) (56 cases, 22%), high-grade squamous intraepithelial lesions (HSIL) (31 cases, 12%), glandular cell abnormalities (30 cases, 11%) and invasive squamous cell carcinoma (21 cases, 9%). The ASC-US/SIL ratio was 1.9%. Invasive adenocarcinoma accounted for 14 cases (4%) with a similar age range as invasive squamous cell carcinoma. Although this study showed a lower incidence and a wider age range of cervical epithelial cell abnormalities than others published internationally, the results emphasize the need for a well-organized cervical screening program supplemented by larger national studies on the pattern of cervical abnormalities in this country. The information provided in this study will encourage use of the Pap smear as a screening method for cervical cancer in developing countries.