Proliferation, cell cycle and apoptosis in cancer
Proliferation, cell cycle and apoptosis in cancer
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DOI：
10.1038/35077213
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发表时间：
2001-05-17
期刊：
影响因子：
64.8
通讯作者：
Vousden, KH
中科院分区：
文献类型：
--
作者：
Evan, GI;Vousden, KH
在每种癌症的复杂性和特发性背后，都隐藏着数量有限的“关键任务”事件，这些事件推动肿瘤细胞及其后代不受控制地扩张和侵袭。其中之一是细胞增殖失调，与支持细胞增殖所需的强制代偿性细胞凋亡抑制一起，提供了支持进一步肿瘤进展所需的最小“平台”。巧妙地针对这些关键事件应该会产生有效且具体的治疗效果。
Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.