New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
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DOI：
10.1016/j.ijantimicag.2020.105938
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发表时间：
2020-05-01
影响因子：
10.8
通讯作者：
Raoult, Didier
中科院分区：
文献类型：
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作者：
Devaux, Christian A;Rolain, Jean-Marc;Raoult, Didier
最近，一种新型冠状病毒（2019-nCoV）在中国出现，正式名称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。尽管采取了严厉的遏制措施，但这种病毒的传播仍在继续。SARS-CoV-2是2019冠状病毒病（COVID-19）的病原体，其特征是人类肺部感染。此后，国际卫生当局的工作重点是迅速诊断和隔离病人，以及寻找能够对付这种疾病最严重影响的疗法。在缺乏已知的有效疗法的情况下，由于公共卫生紧急情况，研究氯喹/羟氯喹对SARS-CoV-2的可能作用是有意义的，因为这种分子以前被描述为大多数冠状病毒（包括SARS-CoV-1）的有效抑制剂。氯喹在中国重新用于治疗COVID-19的初步试验令人鼓舞，导致了几项新的试验。在这里，我们讨论了氯喹干扰SARS-CoV-2复制周期的可能机制。
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.