MAST-CELLS AND HISTAMINE RESPONSES OF THE URETER, ULTRASTRUCTURAL FEATURES OF CELL-TO-CELL ASSOCIATIONS AND FUNCTIONAL IMPLICATIONS
MAST-CELLS AND HISTAMINE RESPONSES OF THE URETER, ULTRASTRUCTURAL FEATURES OF CELL-TO-CELL ASSOCIATIONS AND FUNCTIONAL IMPLICATIONS
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DOI：
10.1007/bf00263637
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发表时间：
1988-01-01
影响因子：
--
通讯作者：
SABHA, M
中科院分区：
文献类型：
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作者：
UGAILYTHULESIUS, L;THULESIUS, O;SABHA, M
在这项研究中，正常成人和绵羊输尿管，一个典型的肥大细胞的大人口的特征性分布描述了光镜和电镜。药理学研究被用来归因于这些细胞在正常和病理状态下的功能作用。在结构研究中，在平滑肌细胞附近发现了典型的肥大细胞，其细胞质中充满了特征性的电子致密颗粒。肥大细胞与成纤维细胞样La细胞和无髓鞘神经纤维之间存在密切联系。肥大细胞的患病率较高，在人类输尿管。人和羊的离体输尿管环均表现出自发性节律性收缩。加入组胺（10-6 - 10 - 5）可诱导收缩频率增加，并增强基础张力，尤其是在人体样本中。在病理条件下，如肾绞痛和炎症反应，可能是组胺从输尿管内的肥大细胞中释放出来，并诱导强烈收缩和疼痛纤维刺激的状态。
In this study of normal adult human and ovine ureters, a characteristic distribution of a large population of typical mast cells was described by light and electron microscopy. Pharmacological studies were used to ascribe a functional role for these cells in normal and pathological states. In the structural investigations typical mast cells with their cytoplasm packed with characteristic electron dense granules were found in close vincinity to smooth muscle cells. A close association between mast cells and a fibroblast like La-cell and non myelinated nerve fibers was noted. The prevalence of mast cells was higher in human ureters. Human and sheep ureterial ring preparations exhibited spontaneous rhythmical contractions in vitro. Addition of histamine (10-6 -10-5) induced an increase in the frequency of contractions and enhanced the basal tone particularly in human samples. It is likely histamine under pathological conditions such as renal colic and inflammatory reactions is released from mast cells within the ureter and induces a state of forceful contractions and pain fibre stimulation.