Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine.
Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine.
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急性冠状动脉闭塞期间清醒狗的局部心肌功能以及对吗啡、普萘洛尔、硝酸甘油和利多卡因的反应。
DOI：
10.1161/01.cir.53.2.302
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发表时间：
1976
期刊：
影响因子：
37.8
通讯作者：
S. Sasyama
中科院分区：
文献类型：
--
作者：
P. Théroux;J. Ross;D. Franklin;W. Kemper;S. Sasyama
在非麻醉犬冠状动脉回旋支闭塞后，用微小的超声晶体对植入左心室心内膜下测量对照长度、边缘长度和缺血长度，以研究局部心肌功能。早在冠状动脉闭塞后5次，缺血区功能明显降低，心率增加(78~115次/分钟)，平均25秒。在控制区，短轴缩短率最初从一个恒定的舒张末长度增加，但后来舒张末长度也增加了7.5%。在90秒时，随着缺血区的全收缩扩张，边缘区的缩短减少了50%。在再灌注时，收缩功能在几分钟内恢复正常，而原舒张期异常持续长达45分钟。当冠状动脉闭塞超过两分钟时，大多数狗表现出觉醒和进一步的心动过速；这种反应可以被吗啡阻止。两分钟内..。
Regional myocardial function following occlusions of the circumflex coronary artery was studied in unanesthetized dogs using minature ultrasonic crystal pairs implanted subendocardially within the left ventricle for measurement of control, marginal, and ischemic lengths. As early as five beats after coronary occlusion, reduced function was apparent in ischemic zones, and an increase in heart rate occurred (78 to 115 beats/min) at an average of 25 sec. In the control zones, shortening initially increased from a constant end-diastolic length, but later end-diastolic length also increased by 7.5%. Shortening in the marginal zones was reduced by 50% at 90 sec as holosystolic expansion developed in the ischemic zones. On reperfusion, systolic function returned to normal within a few minutes while protodiastolic abnormalities persisted for up to 45 min. With coronary occlusions longer than two minutes most dogs exhibited arousal and further tachycardia; this reaction was prevented by morphine. During two minute...