Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
复制标题
儿童和青少年精神病学中的精神药理学：过去七年的回顾。
DOI：
10.1097/00004583-199510000-00011
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Cueva,JE
中科院分区：
文献类型：
--
作者：
Campbell,M;Cueva,JE
目的对过去7年发表的有关精神活性药物治疗品行障碍、精神分裂症、分离焦虑障碍、选择性缄默症、强迫症、恐慌症、重度抑郁症、双相情感障碍、睡眠和饮食障碍的有效性和安全性的文献进行综述。方法回顾双盲、安慰剂对照试验和开放研究的报告，并选择研究进行介绍。结果采用更大的诊断同质患者样本和更复杂的设计和方法导致大多数这些条件的治疗进展。关于该年龄组锂的剂量范围和安全性的数据已经积累，并且有支持性证据表明锂有助于减少攻击。结论为寻求合理的治疗方法，需要进一步研究，特别是在抑郁症和品行障碍方面；应调查心理-社会-环境因素和可能的生物学标记，以确定需要心理药理学治疗的儿童和对社会心理干预或两者结合有反应的儿童。必须确定需要药物治疗的症状和对心理社会干预有反应的症状。
OBJECTIVETo present a critical overview of the selected literature published in the past 7 years on the efficacy and safety of psychoactive agents in conduct disorder, schizophrenia, separation anxiety disorder, selective mutism, obsessive-compulsive disorder, panic disorder, major depressive disorder, bipolar disorder, and sleep and eating disorders.METHODReports of double-blind and placebo-controlled trials and open studies were reviewed and selected studies presented.RESULTSEmployment of larger samples of diagnostically homogeneous patients and a more sophisticated design and methodology led to progress in the treatment of most of these conditions. Data have been accumulated on dose range and safety of lithium in this age group, and there is supportive evidence that lithium is useful in reducing aggression.CONCLUSIONSFor a rational treatment approach, further studies are needed, particularly in depression and conduct disorder; psychosocial-environmental contributions and possible biological markers should be investigated in order to identify children who require psychopharmacological treatments and those who will respond to psychosocial interventions or the combination of both. Symptoms targeted to require pharmacotherapy and symptoms targeted to respond to psychosocial interventions have to be identified.