In Situ Cross-Linking as a Platform for the Synthesis of Triblock Copolymer Vesicles with Diverse Surface Chemistry and Enhanced Stability via RAFT Dispersion Polymerization
In Situ Cross-Linking as a Platform for the Synthesis of Triblock Copolymer Vesicles with Diverse Surface Chemistry and Enhanced Stability via RAFT Dispersion Polymerization
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DOI：
10.1021/acs.macromol.6b02651
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发表时间：
2017-03
期刊：
影响因子：
5.5
通讯作者：
Ling Zhang;Qunzan Lu;X. Lv;Liangliang Shen;Baohua Zhang;Zesheng An
中科院分区：
文献类型：
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作者：
Ling Zhang;Qunzan Lu;X. Lv;Liangliang Shen;Baohua Zhang;Zesheng An
嵌段共聚物囊泡存在一个内在的困境-使用长/带电稳定嵌段提高囊泡的胶体稳定性降低了向囊泡形态转变的倾向。此外，维持囊泡形态需要通过交联的有效结构稳定。我们报告了一种策略，以规避这个问题，同时提高通过聚合诱导自组装（比萨）使用分散聚合合成的囊泡的胶体和结构稳定性。更具体地，原位交联聚N，N-二甲基丙烯酰胺-b-聚首先通过水分散聚合合成（双丙酮丙烯酰胺-共-烯丙基丙烯酰胺）二嵌段共聚物囊泡，然后将其用作稳健的平台以引发中性聚丙烯酰胺或聚丙烯酰胺的第三亲水嵌段的生长。N，N-二甲基丙烯酰胺、阴离子聚（2-丙烯酰胺基-2-甲基-1-丙磺酸钠）或阳离子聚（3-丙烯酰胺丙基三甲基氯化铵）。
An intrinsic dilemma exists for block copolymer vesicles—improving the colloidal stability of vesicles using long/charged stabilizing blocks lowers the propensity of morphological transition to vesicles. Moreover, maintaining the vesicular morphology requires effective structure stabilization via cross-linking. We report a strategy to circumvent this problem and simultaneously improve the colloidal and structural stability of vesicles synthesized via polymerization-induced self-assembly (PISA) using dispersion polymerization. More specifically, in situ cross-linked poly(N,N-dimethylacrylamide)-b-poly(diacetone acrylamide-co-allylacrylamide) diblock copolymer vesicles are first synthesized via aqueous dispersion polymerization, which then serve as a robust platform to initiate the growth of a third hydrophilic block of either neutral poly(N,N-dimethylacrylamide), anionic poly(2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt), or cationic poly(3-acrylamidopropyl trimethylammonium chloride) with reta...