Quantitative analysis of sandwiching recycle technique in preparative linear chromatography
Quantitative analysis of sandwiching recycle technique in preparative linear chromatography
复制标题
制备型线性色谱中夹心回收技术的定量分析
DOI：
10.1252/jcej.30.406
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发表时间：
1997
影响因子：
0.8
通讯作者：
M. Ishida
中科院分区：
文献类型：
--
作者：
K. N. Ghimire;M. Ishida
研究了一种名为“夹心回收”的新回收技术，并检查了其通过色谱分离从多组分混合物中获得高回收率所需组分的有效性。该技术通过将进料期夹在回收期之间来阻碍产品扩散。研究发现，夹心循环色谱对于提高平均保留时间等于其切换时间的组分的产率非常有效，但这种循环并不能提高产品中不纯组分的产率。由于其设备简单，该技术可用于混合物的制备规模分离。通过模拟检查回收方法的详细特征，以识别应考虑哪些条件来从混合物中分离目标成分并获得高产率。
A new recycling technique named “Sandwiching recycle” is investigated, and its effectiveness in obtaining high recovery yields of the desired component from a multicomponent mixture by means of chromatographic separation is examined. This technique hinders the product from diffusion in such a way that the feed period is sandwiched in between the recycle periods. It is found that sandwiching recycle chromatography is highly effective to increase the yield of the component whose mean retention time is equivalent to its switching time, but that this recycling does not increase the yield of the impure component in the product. Because of the simpleness of its apparatus, this technique can be used for preparative scale separation of mixtures. Detailed features of the recycling method are examined by simulation to recognize what conditions should be taken into consideration to separate the target component from a mixture and to obtain high yield.