Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke
Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke
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DOI：
10.1161/01.str.0000019125.80118.99
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发表时间：
2002-07-01
期刊：
影响因子：
8.3
通讯作者：
Zeumer, H
中科院分区：
文献类型：
--
作者：
Kucinski, T;V채terlein, O;Zeumer, H
背景和目的：磁共振弥散加权成像对于检测急性缺血性脑卒中的受限水分子弥散非常敏感。CT对缺血性水肿的净水摄取敏感。我们比较了在扩散加权磁共振成像与CT密度变化的表观扩散系数（ADC）的下降，研究扩散限制和水的吸收之间的相关性在急性中风patients. Methods-25例急性缺血性中风的前脑循环进行MR和CT成像症状发作后1.3至5.4小时。将ADC和CT数据转换到一个共同的三维空间，并将ADC降低的区域（dADC）叠加到相应的CT上。结果ADC（dADC）平均下降170+/-53x10（-6）mm（2）/s，对应CT密度下降（dCT）1.3+/-0.7 HU。dCT呈连续线性下降，下降幅度为0.4HU/h（r=0.55，P
Background and Purpose-Diffusion-weighted MR imaging is very sensitive for the detection of restricted molecular water diffusion in acute ischemic stroke. CT is sensitive to net water uptake in ischemic edema. We compared the decrease in the apparent diffusion coefficient (ADC) in diffusion-weighted MR imaging with CT density changes to study the correlation between diffusion restriction and water uptake in acute stroke patients.Methods-Twenty-five patients with acute ischemic stroke of the anterior cerebral circulation underwent MR and CT imaging 1.3 to 5.4 hours after symptom onset. ADC and CT data were transferred into a common 3-dimensional space, and regions of decreased ADC (dADC) were superimposed onto the corresponding CT. Mean values of ADC and Hounsfield units (HU) were determined in comparison with the nonaffected hemisphere.Results-Mean decrease in ADC (dADC) was 170+/-53x10(-6) mm(2)/s and corresponded to a decrease (dCT) in CT density of 1.3+/-0.7 HU. dCT showed a continuous linear decrease of 0.4 HU/h (r=0.55, P