Inhibin B and Antimullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
Inhibin B and Antimullerian Hormone as Markers of Gonadal Function after Treatment for Medulloblastoma or Posterior Fossa Ependymoma during Childhood
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DOI：
10.1016/j.jpeds.2010.11.019
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发表时间：
2011-06-01
影响因子：
5.1
通讯作者：
Brauner, Raja
中科院分区：
文献类型：
--
作者：
Cuny, Ariane;Trivin, Christine;Brauner, Raja
目的通过测定血浆卵泡刺激素（B）和抗苗勒管激素（AMH）水平，探讨下丘脑-垂体和脊髓放疗与化疗在髓母细胞瘤和后颅窝室管膜瘤治疗后性腺功能缺陷中的作用结果2例患儿伴部分促性腺激素缺乏，1例伴睾丸功能缺乏。6名男孩FSH水平升高，表明肾小管缺陷，5名男孩伴有Leydig细胞缺陷。七个男孩的水平都是B
Objective To evaluate the roles of hypothalamic-pituitary and spinal irradiations and chemotherapy in gonadal deficiency after treatment for medulloblastoma or posterior fossa ependymoma by measuring levels of plasma inhibin B and antimullerian hormone (AMH).Study design A total of 34 boys and 22 girls were classified as having normal levels of plasma follicle-stimulating hormone (FSH; 9 IU/L) and luteinizing hormone (LH; 5 IUL).Results Two boys had partial gonadotropin deficiency, combined with testicular deficiency in one boy. Six boys had increased levels of FSH, indicating tubular deficiency, combined with Leydig cell deficiency in 5 boys. The 7 boys with inhibin B levels