TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma
TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma
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DOI：
10.3892/ijo_00000736
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发表时间：
2010-10-01
影响因子：
5.2
通讯作者：
Li, Jinjun
中科院分区：
文献类型：
--
作者：
Luo, Hairong;Hao, Xiangfang;Li, Jinjun
肝细胞癌 (HCC) 是一种侵袭性癌症，检测时可能已处于晚期。研究表明，TC21属于Ras超家族成员，与肿瘤细胞的增殖、迁移和转化有关。既往研究表明，TC21在乳腺癌、食管癌和口腔癌中过度表达，且与肿瘤发生的早期阶段密切相关。在本研究中，我们证明TC21过表达可促进体外HCC细胞的运动和体内肝内转移。此外，检测 HCC 细胞中 TC21 异位表达和 siRNA 处理效果的实验表明，TC21 改变了粘附分子 E-钙粘蛋白和 N-钙粘蛋白的表达。我们的数据表明 TC21 与 HCC 的肿瘤进展和不良预后相关。
Hepatocellular carcinoma (HCC) is an aggressive type of cancer, and it may be at an advanced stage when it is detected. It has been shown that TC21, a member of the Ras superfamily, is associated with the proliferation, migration and transformation of tumor cells. Previous studies have shown that TC21 is overexpressed in breast, esophageal and oral carcinomas, and that it is closely associated with the early stages of tumorigenesis. In this study, we demonstrate that TC21 overexpression promotes the motility of HCC cells in vitro and intrahepatic metastasis in vivo. Furthermore, experiments examining the effects of both the ectopic expression of TC21 and siRNA treatment in HCC cells showed that TC21 alters the expression of the adhesive molecules E-cadherin and N-cadherin. Our data suggest that TC21 is associated with tumor progression and poor prognosis in HCC.