DNA METHYLATION AND THE FREQUENCY OF CPG IN ANIMAL DNA
DNA METHYLATION AND THE FREQUENCY OF CPG IN ANIMAL DNA
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DOI：
10.1093/nar/8.7.1499
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发表时间：
1980-01-01
影响因子：
14.9
通讯作者：
BIRD, AP
中科院分区：
文献类型：
--
作者：
BIRD, AP
对动物最近邻二核苷酸频率和DNA甲基化水平的分析有力地支持了5-甲基胞嘧啶(5mC)倾向于异常频繁地突变为T的观点，这一倾向可能是高度甲基化基因组中CpG缺陷的原因。
An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.