SYNAPTONEMAL COMPLEX DAMAGE INDUCED BY CLASTOGENIC AND ANTI-MITOTIC CHEMICALS - IMPLICATIONS FOR NON-DISJUNCTION AND ANEUPLOIDY
SYNAPTONEMAL COMPLEX DAMAGE INDUCED BY CLASTOGENIC AND ANTI-MITOTIC CHEMICALS - IMPLICATIONS FOR NON-DISJUNCTION AND ANEUPLOIDY
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DOI：
10.1016/0027-5107(88)90020-6
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发表时间：
1988-10-01
期刊：
影响因子：
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通讯作者：
MOSES, MJ
中科院分区：
文献类型：
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作者：
ALLEN, JW;GIBSON, JB;MOSES, MJ
用丝裂霉素C、环磷酰胺、安吖啶、秋水仙碱或硫酸长春碱处理小鼠，并分析减数分裂前期细胞的联会复合体（SC）损伤。所有的测试代理引起联会复合体断裂和突触不规则，虽然在S期或前期阶段诱导特定类型的损害的倾向不同的化学品。这些数据表明，SC分析可以揭示化学特异性的减数分裂同源配对/突触尚未普遍认识到，这在理论上可能涉及非分离的改变。
Mice were treated with mitomycin C, cyclophosphamide, amsacrine, colchicine, or vinblastine sulfate, and meiotic prophase cells analyzed for synaptonemal complex (SC) damage. All test agents caused synaptonemal complex breakage and synapsis irregularities, although propensities for inducing specific types of damage at S-phase or prophase stages varied among the chemicals. The data indicate that SC analysis can reveal chemical-specific alterations to meiotic homologue pairing/synapsis which have not generally been recognized, and which theoretically may be implicated in non-disjunction.