BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder.
BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder.
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中国汉族强迫症和广泛性焦虑症人群 BDNF Val66Met 多态性及其血浆水平
DOI：
10.1016/j.jad.2015.07.023
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发表时间：
2015-11
影响因子：
6.6
通讯作者：
Xiao, Zeping
中科院分区：
文献类型：
--
作者：
Fan, Qing;Yu, Shunying;Lin, Zhiguang;Xiao, Zeping
背景焦虑障碍是以焦虑和恐惧为主要特征的精神障碍，包括广泛性焦虑障碍（generalized anxiety disorder，GAD）。强迫症（OCD）在DSM-IV中被归类为焦虑症。然而，强迫症不再包括在焦虑症中，并在DSM-5中被称为强迫症和相关疾病（OCD）。探索强迫症和焦虑症之间是否存在任何不同的生物学特征将是有趣的。脑源性神经营养因子（BDNF）是强迫症和广泛性焦虑症的潜在候选基因。BDNF和强迫症之间的遗传关联研究结果一直不一致。已发现强迫症患者的BDNF血浆/血清水平低于健康对照组。然而，BDNF水平降低的遗传原因尚未得到很好的阐明。关于BDNF和GAD的研究相对较少。本研究的目的是确定是否与强迫症和广泛性焦虑症的BDNF的单核苷酸多态性Val 66 Met，检查血浆BDNF水平在强迫症和广泛性焦虑症，并探讨是否Val 66 Met的变异影响BDNF血浆levels.MethodsWe基因分型Val 66 Met变异在148强迫症患者，108广泛性焦虑症患者和99名健康对照。同时检测113例强迫症患者、102例广泛性焦虑症患者和63例健康对照者血浆BDNF水平。强迫症和广泛性焦虑症患者血浆BDNF水平均显著低于健康对照组。Val 66 Met变异对血浆BDNF水平无影响。强迫症与广泛性焦虑症之间无显著性差异。无论是将强迫症和广泛性焦虑症作为一组还是将两组分开，结果都没有变化。局限性首先，基因分型的样本量相对较小，导致本研究中遗传部分的统计功效较低。其次，我们只对BDNF基因中的一个SNP进行基因分型。第三，部分参与者没有进行BDNF血浆levels.ConclusionsOur研究结果支持的假设，BDNF参与的病理生理学的精神障碍，不仅强迫症，但也广泛性焦虑症。与健康对照组相比，强迫症和广泛性焦虑症患者的BDNF血浆水平均较低。血浆BDNF水平与Val 66 Met变异无关。
BackgroundAnxiety disorders are a category of mental disorders characterized by feelings of anxiety and fear, which include generalized anxiety disorder (GAD). Obsessive-Compulsive Disorder (OCD) used to be categorized as anxiety disorder in DSM-IV. However OCD was no longer included in anxiety disorders and came into its own category titled as Obsessive-Compulsive and Related Disorders (OCRD) in DSM-5. It will be interesting to explore is there any different biological characteristics between OCD and anxiety disorders. Brain-derived neurotrophic factor (BDNF) was a potential candidate gene in both OCD and GAD. The results of genetic association studies between BDNF and OCD have been inconsistent. BDNF plasma/serum levels in OCD have been found lower than those in healthy controls. However the heritable reason of the lowered BDNF levels was not well elucidated. The amount of studies about BDNF and GAD were relatively small. The aims of this study were to determine whether single nucleotide polymorphism Val66Met of BDNF was associated with OCD and GAD, to examine BDNF plasma levels in OCD and GAD, and to explore whether Val66Met variation influences BDNF plasma levels.MethodsWe genotyped Val66Met variation in 148 OCD patients, 108 GAD patients and 99 healthy controls. Within the same sample, BDNF plasma levels were determined in 113 OCD patients, 102 GAD patients and 63 healthy controls.ResultsVal66Met variation was not associated with OCD or GAD. BDNF plasma levels in OCD and GAD patients were significant lower than those in healthy controls. Val66Met variation had no influence on BDNF plasma levels. No difference was found between OCD and GAD. Results do not change no matter taking OCD and GAD as one group or separated two.LimitationsFirst, the sample size for genotyping was relatively small, which leaded to a low statistical power of the genetic part in this study. Second, we genotyped just one SNP in BDNF gene. Third, parts of the participants did not be assayed for BDNF plasma levels.ConclusionsOur findings support the hypothesis that BDNF is involved in the pathophysiology of mental disorders, not only OCD but also GAD. OCD and GAD patients both show lower BDNF plasma levels compared to healthy controls. The BDNF plasma levels are not associated with Val66Met variation.
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