EyeSite: a semi-automated database of protein families in the eye
EyeSite: a semi-automated database of protein families in the eye
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DOI：
10.1093/nar/gkh090
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Slingsby, C
中科院分区：
文献类型：
--
作者：
Lee, DA;Fefeu, S;Slingsby, C
eyeesite是一个基于网络的蛋白质家族数据库，包含在眼睛中起作用的蛋白质及其同源序列。这些资源聚集了不同同源水平的蛋白质，以便于序列的功能注释和结构同源蛋白质的建模。使用TribeMCL算法的新协议，将眼蛋白组织成其功能所在的组织类型，并聚集成同源家族。同源家族进一步细分为序列簇，产生多个序列比对。来自CATH结构域数据库的结构注释提供了近90%的序列，来自Pfam数据库的蛋白质家族注释提供了接近86%的序列。在适当的地方也生成了同源模型。eyeesite存储在关系数据库中，并与其他在线生物信息学资源广泛链接，以帮助将等位基因变异、注释和临床细节与数据库中的衍生数据联系起来。eyeesite可在http://eyesite.cryst.bbk.ac.uk/上进行在线搜索、序列信息和模型检索。
The EyeSite is a web-based database of protein families for proteins that function in the eye and their homologous sequences. The resource clusters proteins at different levels of homology in order to faciltate functional annotation of sequences and modelling of proteins from structural homologues. Eye proteins are organized into the tissue types in which they function and are clustered into homologous families using a novel protocol employing the TribeMCL algorithm. Homologous families are further subdivided into sequence clusters for which multiple sequence alignments are generated. Structural annotations from the CATH domain database are provided for nearly 90% of the sequences, and protein family annotations from the Pfam database for similar to86%. Homology models have also been generated where appropriate. The EyeSite is stored in a relational database and is extensively linked to other online bioinformatics resources to help relate allelic variants, annotations and clinical details to the derived data in the database. The EyeSite is available for online search, sequence information and model retrieval at http://eyesite.cryst.bbk.ac.uk/.