Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent
Measurement of absolute arterial cerebral blood volume in human brain without using a contrast agent
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DOI：
10.1002/nbm.1693
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
van Zijl, Peter C. M.
中科院分区：
文献类型：
--
作者：
Hua, Jun;Qin, Qin;van Zijl, Peter C. M.
动脉脑血容量（CBVa）是组织灌注和血管反应性的重要指标。我们扩展了最近开发的流入血管空间占用（iVASO）MRI技术，该技术使用空间选择性反转来抑制血液流入切片的信号，并使用脑脊液（CSF）进行控制扫描以测量绝对CBVa进行信号归一化。在多个血液归零时间采集图像，以解释跨脑的动脉通过时间的异质性，由此定量CBVa和动脉通过时间。通过结合速度依赖性双极压差单独测定小动脉CBVa。灰质（GM）CBVa值（n=11）分别为2.04 +/- 0.27和0.76 +/- 0.17 ml血液/100 ml组织，无和有压碎器梯度（B=1.8 s/mm 2）。动脉通过时间分别为671 +/- 43和785 +/- 69 ms。通过测量其T2（在动脉范围内）验证信号的动脉起源。所提出的方法不需要外源性造影剂的管理，并提供了一个非侵入性的替代现有的血容量技术映射绝对CBVa在脑生理学和神经血管疾病的研究。版权所有（C）2011约翰威利父子有限公司
Arterial cerebral blood volume (CBVa) is a vital indicator of tissue perfusion and vascular reactivity. We extended the recently developed inflow vascular-space-occupancy (iVASO) MRI technique, which uses spatially selective inversion to suppress the signal from blood flowing into a slice, with a control scan to measure absolute CBVa using cerebrospinal fluid (CSF) for signal normalization. Images were acquired at multiple blood nulling times to account for the heterogeneity of arterial transit times across the brain, from which both CBVa and arterial transit times were quantified. Arteriolar CBVa was determined separately by incorporating velocity-dependent bipolar crusher gradients. Gray matter (GM) CBVa values (n=11) were 2.04 +/- 0.27 and 0.76 +/- 0.17 ml blood/100 ml tissue without and with crusher gradients (b=1.8 s/mm2), respectively. Arterial transit times were 671 +/- 43 and 785 +/- 69 ms, respectively. The arterial origin of the signal was validated by measuring its T2, which was within the arterial range. The proposed approach does not require exogenous contrast agent administration, and provides a non-invasive alternative to existing blood volume techniques for mapping absolute CBVa in studies of brain physiology and neurovascular diseases. Copyright (C) 2011 John Wiley & Sons, Ltd.