Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin
Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin
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DOI：
10.1093/ajcn/76.3.595
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发表时间：
2002-09-01
影响因子：
7.1
通讯作者：
van Poppel, G
中科院分区：
文献类型：
--
作者：
Broekmans, WMR;Berendschot, TTJM;van Poppel, G
背景：黄斑色素集中在视网膜中央区域，含有类胡萝卜素、叶黄素和玉米黄质。低MP密度可能是老年性黄斑变性的危险因素。在一般人群中，MP密度与血清叶黄素、玉米黄质和脂肪叶黄素浓度之间的关系的信息很少。目的：考虑人群中潜在的混杂因素，研究MP密度与血清叶黄素、血清玉米黄质和脂肪叶黄素浓度之间的关系。设计：招募年龄为18-75岁的志愿者(n=376)。在横断面设计中，分析了376例血清和187例脂肪组织中的类胡萝卜素，并用眼底反射法测定MP密度。结果：总研究组的MP平均密度为0.33+/-0.15。男性的MP密度比女性高13%(P<；0.05)。女性的血清和血液中的α-生育酚、维生素C和除番茄红素以外的所有类胡萝卜素的浓度都显著较高。女性的脂肪叶黄素浓度也显著高于男性。回归模型显示，在调整年龄后，男性的MP密度与血清叶黄素、血清玉米黄质和脂肪叶黄素浓度呈显著正相关，而女性则没有相关性。在男性中，在调整了年龄、总胆固醇、体重指数和吸烟后，MP密度与MP密度仍然显著相关。结论：MP密度与血清叶黄素、血清玉米黄质和脂肪叶黄素浓度的相关性在男性要强于女性。
Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population.Objective: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population.Design: Volunteers (n = 376) aged 18-75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance.Results: Mean MP density in the total study group was 0.33 +/- 0.15. MP density was 13% higher in men than in women (P < 0.05). Serum and blood concentrations of a-tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking.Conclusion: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women.