Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years
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DOI：
10.1016/j.jpeds.2020.08.014
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发表时间：
2020-11-01
影响因子：
5.1
通讯作者：
de Vries, Linda S.
中科院分区：
文献类型：
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作者：
Cizmeci, Mehmet N.;Groenendaal, Floris;de Vries, Linda S.
目的比较脑室扩大低阈与高阈干预对出血性脑室扩张早产儿死亡或严重神经发育障碍的影响。这项多中心随机对照试验回顾了在低阈值（脑室指数为bbbp97，前角宽度为> 6mm）或高阈值（脑室指数为bbbp97 + 4mm，前角宽度为b> 10mm）后进行腰椎穿刺的情况。复合不良结局定义为死亡或脑瘫或Bayley复合认知/运动评分
Objective To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.Study design This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores