Input organization of distal and proximal forelimb areas in the monkey primary motor cortex: A retrograde double labeling study
Input organization of distal and proximal forelimb areas in the monkey primary motor cortex: A retrograde double labeling study
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DOI：
10.1002/cne.903330206
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发表时间：
1993-07
影响因子：
2.5
通讯作者：
H. Tokuno;J. Tanji
中科院分区：
文献类型：
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作者：
H. Tokuno;J. Tanji
目前的双标记研究旨在证明在协调的远、近侧前肢运动中的运动控制的形态框架，这可能至少部分地依赖于初级运动皮质前肢区域的皮质和丘脑皮质的输入。在对4只猕猴的初级运动皮质进行皮质内微刺激定位后，尝试用荧光染料进行逆行追踪研究，以同时标记皮质和皮质下投射到前肢远侧代表区域和投射到初级运动皮质近侧代表区域的神经元。投射到初级运动皮质前肢远端和近端的神经元主要分布在以下区域：运动前区、初级体感区、次级体感区、第5区和丘脑。相反，在辅助运动区、扣带运动区、邻近注射部位的初级运动皮质、屏状核和Meynert基底核，标记的投射神经元没有精确的地形图组织。本研究表明，初级运动皮质的前肢区域接受来自皮质和皮质下来源的分离和混合输入。特别是，初级运动皮质的前肢区接受来自运动前区的地形组织的输入，以及来自辅助运动区和扣带运动区的非地形组织的输入，这一事实表明额叶运动前区在控制协调的远端和近端的前肢运动中可能具有不同的功能。©1993 Wiley-Liss，Inc.
The present double‐labeling study was designed to demonstrate the morphological framework for motor control in coordinated distal and proximal forelimb movements, which may partly, at least, depend on corticocortical and thalamocortical inputs to the forelimb area in the primary motor cortex. After intracortical microstimulation mapping of the forelimb area in the primary motor cortex of four macaque monkeys, a retrograde tracing study with fluorescent dyes was attempted to label simultaneously neurons in cortical and subcortical sites projecting to the distal forelimb representation area and those projecting to the proximal representation area of the primary motor cortex. Neurons projecting to distal and proximal forelimb parts of the primary motor cortex were largely separate in the following areas: the premotor area, primary somatosensory area, secondary somatosensory area, area 5, and thalamus. In contrast, there was no precise topographic organization of labeled projection neurons in the following areas: the supplementary motor area, cingulate motor area, primary motor cortex adjacent to the injection sites, claustrum, and basal nucleus of Meynert. The present study revealed that the forelimb area of the primary motor cortex receives both segregated and intermixed inputs from cortical and subcortical sources. In particular, the fact that the forelimb area of the primary motor cortex receives topographically organized inputs from the premotor area and nontopographically organized inputs from the supplementary motor area and cingulate motor area indicates possible different functional roles of frontal premotor areas in control of coordinated distal and proximal forelimb movements. © 1993 Wiley‐Liss, Inc.