Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.
Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases.
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DOI：
10.1155/2012/729290
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发表时间：
2012
影响因子：
--
通讯作者：
Campello S
中科院分区：
文献类型：
--
作者：
Corrado M;Scorrano L;Campello S
线粒体是细胞中的关键细胞器，具有基本功能，从生物合成和代谢途径到氧化磷酸化和ATP产生，从钙缓冲到red-ox稳态和凋亡信号传导途径。线粒体也是动态细胞器，不断融合和分裂，其定位，大小和运输受到精细调控。此外，近几十年来，线粒体功能和动力学的改变与越来越多的疾病有关。在这篇综述中，我们专注于线粒体动力学与癌症，神经退行性疾病和神经炎症性疾病之间的关系迄今澄清。
Mitochondria are key organelles in the cell, hosting essential functions, from biosynthetic and metabolic pathways, to oxidative phosphorylation and ATP production, from calcium buffering to red-ox homeostasis and apoptotic signalling pathways. Mitochondria are also dynamic organelles, continuously fusing and dividing, and their localization, size and trafficking are finely regulated. Moreover, in recent decades, alterations in mitochondrial function and dynamics have been implicated in an increasing number of diseases. In this review, we focus on the relationship clarified hitherto between mitochondrial dynamics and cancer, neurodegenerative and neuroinflammatory diseases.