Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales.
Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales.
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DOI：
10.1136/sextrans-2020-054598
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Hood K
中科院分区：
文献类型：
--
作者：
Gillespie D;Knapper C;Hughes D;Couzens Z;Wood F;de Bruin M;Ma R;Jones AT;Williams A;Hood K
描述COVID-19和相关控制措施对威尔士暴露前预防（PrEP）使用者性行为的早期影响。数据来自PrEP使用和性行为的生态瞬时评估研究。参与者是通过威尔士四个卫生委员会的国家卫生服务（NHS）性健康诊所获得预防措施的个人。研究人员分析了2020年2月3日至2020年5月10日期间记录前一周无安全套性行为的每周数据。从2020年3月16日开始的那一周，威尔士采取了社交距离措施，性健康诊所也发生了变化。两级逻辑回归模型拟合了无安全套性行为（是/否）随时间的变化，包括一个从2020年3月16日开始的一周的指标，并扩展到探索关系状态和性健康诊所之间的差异关联。数据来自56名参与者，包括697人周（可获得最大人数的89%）。平均而言，42%的参与者报告在引入社交距离措施之前有无安全套性行为，20%的参与者报告在引入社交距离措施之后有无安全套性行为（OR=0.16, 95% CI 0.07至0.37,p<0.001）。有一些证据表明，这种关联受到关系状态的调节（单身参与者的OR =0.09, 95% CI 0.06至0.23；非单身参与者的OR =0.46, 95% CI 0.16至1.25）。在威尔士各地引入社会距离措施和改变PrEP服务，与受访者中报告的无避孕套性行为的显著减少有关，单身人士的减少幅度比单身人士更大。COVID-19和相关控制措施对这一人群身心健康和福祉的长期影响需要密切关注。
To describe the early impact of COVID-19 and associated control measures on the sexual behaviour of pre-exposure prophylaxis (PrEP) users in Wales. Data were obtained from an ecological momentary assessment study of PrEP use and sexual behaviour. Participants were individuals accessing PrEP through the National Health Service (NHS) sexual health clinics across four health boards in Wales. Weekly data documenting condomless sex in the preceding week were analysed between 03/02/2020 and 10/05/2020. The introduction of social distancing measures and changes to sexual health clinics in Wales occurred on the week starting 16/03/2020. Two-level logistic regression models were fitted to condomless sex (yes/no) over time, included an indicator for the week starting 16/03/2020, and were extended to explore differential associations by relationship status and sexual health clinic. Data were available from 56 participants and included 697 person-weeks (89% of the maximum number that could have been obtained). On average, 42% of participants reported condomless sex in the period prior to the introduction of social distancing measures and 20% reported condomless sex after (OR=0.16, 95% CI 0.07 to 0.37, p<0.001). There was some evidence to suggest that this association was moderated by relationship status (OR for single participants=0.09, 95% CI 0.06 to 0.23; OR for not single participants=0.46, 95% CI 0.16 to 1.25). The introduction of social distancing measures and changes to PrEP services across Wales was associated with a marked reduction in reported instances of condomless sexual intercourse among respondents, with a larger reduction in those who were single compared with those who were not. The long-term impact of COVID-19 and associated control measures on this population’s physical and mental health and well-being requires close examination.
影响因子：
3.6
作者：
Knapper, Carys;Birley, Humphrey;Parker, Irene
通讯作者：
Parker, Irene
影响因子：
3.5
作者：
Eubank, S.;Eckstrand, I;Barrett, C. L.
通讯作者：
Barrett, C. L.
DOI：
10.1056/nejmoa1011205
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Grant RM;Lama JR;Anderson PL;McMahan V;Liu AY;Vargas L;Goicochea P;Casapía M;Guanira-Carranza JV;Ramirez-Cardich ME;Montoya-Herrera O;Fernández T;Veloso VG;Buchbinder SP;Chariyalertsak S;Schechter M;Bekker LG;Mayer KH;Kallás EG;Amico KR;Mulligan K;Bushman LR;Hance RJ;Ganoza C;Defechereux P;Postle B;Wang F;McConnell JJ;Zheng JH;Lee J;Rooney JF;Jaffe HS;Martinez AI;Burns DN;Glidden DV;iPrEx Study Team
通讯作者：
iPrEx Study Team