Correlation of triglyceride to high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease among the non-obese Chinese population with normal blood lipid levels: a retrospective cohort research
Correlation of triglyceride to high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease among the non-obese Chinese population with normal blood lipid levels: a retrospective cohort research
复制标题
血脂正常的非肥胖中国人群甘油三酯与高密度脂蛋白胆固醇比值与非酒精性脂肪肝的相关性：一项回顾性队列研究
DOI：
10.1186/s12944-019-1104-6
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发表时间：
2019-08-09
影响因子：
4.5
通讯作者：
Chen, Youren
中科院分区：
文献类型：
--
作者：
Chen, Zekai;Qi, Hailun;Chen, Youren
尽管非酒精性脂肪性肝病(NAFLD)常见于代谢异常患者，但也可见于非肥胖者。甘油三酯/高密度脂蛋白胆固醇(TG/HDLC)的比值被认为是NAFLD的预测因素。然而，在血脂水平正常的非肥胖中国人中，甘油三酯/高密度脂蛋白胆固醇比值与非肥胖性脂肪肝的相关性仍难以确定。本研究旨在分析中国非肥胖人群中无血脂异常人群的甘油三酯/高密度脂蛋白胆固醇比值与非肥胖性脂肪肝的相关性。结果在中位随访2.9 年期间，非肥胖者的累积发病率为8.69%，同时其发病率在甘油三酯/高密度脂蛋白胆固醇比值的四分位数(分别为0.61、1.28、2.55和4.25%)范围内逐渐升高。然后对多变量因素进行调整。多因素COX回归分析结果显示，高四分位(Q2~Q4)NAFLD的危险比分别为2.10(1.33~3.32)、3.11(2.03~4.75)和3.40(2.24~5.17)。甘油三酯/高密度脂蛋白胆固醇比值受试者特征曲线下面积男性为0.70(0.68~0.72)，女性为0.72(0.70~0.75)。结论在无血脂异常的非肥胖人群中，TG/HDLc与NAFLD之间存在独立关系，TG/HDLc可作为NAFLD的一个较好的预测指标。
BackgroundAlthough nonalcoholic fatty liver disease (NAFLD) is commonly seen in metabolic abnormalities patients, NAFLD is also occurred in the non-obese individuals. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is considered as a predictive factor of NAFLD. However, it is still difficult to confirm the correlation of TG/HDL-C ratio with NAFLD among non-obese Chinese people with normal blood lipid levels. In our study, it is aimed to analyze the correlation of TG/HDL-C ratio with NAFLD among non-obese Chinese population without dyslipidemia.MethodsIn the retrospective cohort study, 9838 non-obese subjects who were free of NAFLD were enrolled. NAFLD was diagnosed by ultrasonography.ResultsDuring the median follow-up period of 2.9 years, cumulative incidence of NAFLD in non-obesity individuals was 8.69% among the overall population; meanwhile, its incidence was gradually enhanced across the quartiles of TG/HDL-C ratio (0.61, 1.28, 2.55 and 4.25% respectively). Then the multivariate factors were adjusted. The multivariate cox regression analysis results showed that the hazard ratio of NAFLD in higher quartiles (Q2-Q4) was 2.10 (1.33–3.32), 3.11 (2.03–4.75) and 3.40 (2.24–5.17), respectively. Besides, the area under receiver operator characteristic curve (AUC) of TG/HDL-C ratio in the male was 0.70 (0.68–0.72) and 0.72 (0.70–0.75) in the female. The final values were dramatically larger than the other lipid index.ConclusionThere is an independent relationship between TG/HDL-C and NAFLD among non-obese Chinese population without dyslipidemia, and TG/HDL-C may be used as a better predictor for NAFLD.