Vegetable protein and fiber from cereal are inversely associated with the risk of hypertension in a Spanish cohort
Vegetable protein and fiber from cereal are inversely associated with the risk of hypertension in a Spanish cohort
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DOI：
10.1016/j.arcmed.2006.01.007
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发表时间：
2006-08-01
影响因子：
7.7
通讯作者：
Martinez-Gonzalez, Miguel Angel
中科院分区：
文献类型：
--
作者：
Alonso, Alvaro;Jose Beunza, Juan;Martinez-Gonzalez, Miguel Angel
背景。一些横断面研究表明，纤维和蛋白质的摄入可能与较低的血压水平有关，但来自前瞻性队列的结果很少，而且没有在美国方法之外进行过。SUN队列对5880名20岁以上的西班牙男性和女性进行了前瞻性随访，他们都是大学毕业生。饮食信息在基线时通过先前验证的半定量食物频率问卷收集。新病例的医学诊断高血压（HT）是在招募至少2年后通过邮寄问卷的回答来确定的。在中位随访28个月后，确定了180例新发HT病例。在对潜在混杂因素和一些饮食因素进行调整后，植物蛋白摄入量最高的五分位数的参与者与最低的五分位数的参与者相比，发生HT的风险更低[风险比(HR) = 0.5, 95%可信区间（Cl） 0.2-0.9， p为趋势= 0.06]。同样，谷物纤维与较低的HT风险呈负相关（第五分位数与第一分位数的比值为0.6,95% Cl为0.3-1.0，p为趋势值= 0.05）。降低风险在男性、肥胖者和老年人中更为重要。总蛋白或动物蛋白和总纤维以及来自谷类以外的其他来源的纤维与ht的风险无关。在这个地中海队列中，当考虑到其他营养素时，从谷物中摄入植物蛋白和纤维与较低的HT风险相关。(c) 2006年度Elsevier Inc.出版。
Background. Some cross-sectional studies suggest that fiber and protein intake can be associated with lower levels of blood pressure, but results from prospective cohorts are scarce and none has been conducted outside the U.S.Methods. The SUN cohort followed-up prospectively 5880 Spanish men and women older than 20 years of age, all university graduates. Dietary information was gathered at baseline with a previously validated semiquantitative food frequency questionnaire. New cases of medically diagnosed hypertension (HT) were identified through responses to a mailed questionnaire after at least 2 years from recruitment.Results. One hundred and eighty new cases of HT were ascertained after a median follow-up of 28 months. After adjustment for potential confounders and several dietary factors, participants in the highest quintile of vegetable protein intake had a lower risk of incident HT compared with those in the lowest quintile [hazard ratio (HR) = 0.5, 95% confidence interval (Cl) 0.2-0.9, p for trend = 0.06]. Similarly, fiber from cereals was inversely associated with a lower risk of HT (HR comparing fifth vs. first quintile = 0.6, 95% Cl 0.3-1.0, p for trend = 0.05). Risk reduction was more important among men and obese and older individuals. Total or animal protein and total fiber as well as fiber from other sources different from cereal were not associated with the risk of HT.Conclusions. In this Mediterranean cohort, dietary intake of vegetable protein and fiber from cereals was associated with a lower risk of HT when other nutrients were also taken into consideration. (C) 2006 IMSS. Published by Elsevier Inc.