Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers.
Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers.
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DOI：
10.1039/c7py00196g
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Sumerlin BS
中科院分区：
文献类型：
--
作者：
Alfurhood JA;Sun H;Kabb CP;Tucker BS;Matthews JH;Luesch H;Sumerlin BS
我们报告了基于N-（2-羟丙基）甲基丙烯酰胺（HPMA）的嵌段共聚物的纳米组装体，其中药物裂解通过HPMA单元的再生来增强原始聚合物载体的生物相容性。通过酯水解的药物释放表明这种方法提供了在酸性条件下刺激响应性药物递送的潜力。
We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.