Reward-related fMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation
Reward-related fMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation
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DOI：
10.1016/j.neuron.2005.01.010
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发表时间：
2005-02-03
期刊：
影响因子：
16.2
通讯作者：
Düzel, E
中科院分区：
文献类型：
--
作者：
Wittmann, BC;Schott, BH;Düzel, E
来自中脑结构（如黑质）的多巴胺能输入可以增强和延长海马体的长时程增强作用。据推测，这种改善的突触可塑性与海马体更好的记忆巩固有关。我们使用一种能够可靠地引发多巴胺能反应（奖励预期）的条件来研究健康成年人多巴胺能中脑区域的活动与海马长期记忆之间的关系。与非奖励预测图片相比，预测金钱奖励的物体图画图片与奖励相关大脑区域（包括黑质）的功能磁共振成像活动更强相关。三周后，奖励预测的回忆和源记忆比非奖励预测的图片更好。与后来被遗忘的图片相比，后来识别的奖励预测图片的海马体和中脑的 FMRI 活动更高。这些数据与以下假设一致：多巴胺能中脑区域的激活可能通过增强巩固来增强海马依赖性记忆形成。
Long-term potentiation in the hippocampus can be enhanced and prolonged by dopaminergic inputs from midbrain structures such as the substantia nigra. This improved synaptic plasticity is hypothesized to be associated with better memory consolidation in the hippocampus. We used a condition that reliably elicits a dopaminergic response, reward anticipation, to study the relationship between activity of dopaminergic midbrain areas and hippocampal long-term memory in healthy adults. Pictures of object drawings that predicted monetary reward were associated with stronger fMRI activity in reward-related brain areas, including the substantia nigra, compared with non-reward-predicting pictures. Three weeks later, recollection and source memory were better for reward-predicting than for non-reward-predicting pictures. FMRI activity in the hippocampus and the midbrain was higher for reward-predicting pictures that were later recognized compared with later forgotten Pictures. These data are consistent with the hypothesis that activation of dopaminergic midbrain regions enhances hippocampus-dependent memory formation, possibly by enhancing consolidation.