Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation
Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation
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DOI：
10.1016/j.phymed.2007.08.002
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发表时间：
2008-04-01
期刊：
影响因子：
7.9
通讯作者：
Jamal, J. A.
中科院分区：
文献类型：
--
作者：
Jantan, I.;Raweh, S. M.;Jamal, J. A.
从野山姜中分离得到12个化合物，山柰，姜黄，评价了姜黄（Curcuma aromatica Valeton）和姜黄素（Curcuma zerumbet Smith）以及三种合成的黄根醇衍生物抑制人全血中花生四烯酸（AA）、胶原蛋白和ADP诱导的血小板聚集的能力。化合物的抗血小板活性通过Chrono Log全血聚集计使用电阻抗方法在体外测量。在所测试的化合物中，来自C aromatica的姜黄素、来自A.结果表明，圆叶克百威（Krotunda）的3-deacetylcrotepoxide和Mutica对AA诱导的血小板聚集有较强的抑制作用，IC_（50）值小于84 μ M。姜黄素是最有效的抗血小板化合物，因为它抑制AA-，胶原蛋白和ADP诱导的血小板聚集，IC 50值分别为37.5，60.9和45.7 μ M。(C)2007年，Elsevier GmbH。All rights reserved.
Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from C aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from A. mutica and 3-deacetylcrotepoxide from K rotunda showed strong inhibition on platelet aggregation induced by AA with IC50 values of less than 84 mu M. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC50 values of 37.5, 60.9 and 45.7 mu M, respectively. (C) 2007 Elsevier GmbH. All rights reserved.