Apathy in frontotemporal dementia: Behavioral and neuroimaging correlates
Apathy in frontotemporal dementia: Behavioral and neuroimaging correlates
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DOI：
10.1155/2012/286427
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
--
作者：
Eslinger, Paul J.;Moore, Peachie;Grossman, Murray
我们调查了额颞叶痴呆(FTD)患者，特别是那些有行为变异性社交和执行缺陷(BvFTD)的患者，以冷漠的形式发生目标导向动机变化的情况。标准化的行为问卷被用来调查和比较患者和照顾者的冷漠程度。在bvFTD的病例中，冷漠评分与社会认知、执行功能和脑MRI上的萎缩程度进一步相关。结果表明，护理人员将bvFTD患者评为明显提高了冷漠评分，尽管患者自我评分正常。进行性非流利性失语和语义性痴呆的FTD样本的照顾者和自我评分与健康对照组和他们的告密者没有区别。在bvFTD示例中。照顾者冷漠得分与一般认知筛查或抑郁得分无关，但与社会认知和执行功能测量显著相关。基于体素的形态计量学显示，bvFFD的冷漠程度与右侧尾状核(包括腹侧纹状体)、右侧颞顶交界处、右侧后下中回和左侧额盖-前岛区的显著萎缩有关。研究结果表明，bvFTD与目标导向的动机行为的显着崩溃有关，包括皮质-基底节回路的中断，这也与社会和执行功能缺陷有关。
We investigated the occurrence of goal-directed motivational change in the form of apathy in patients with frontotemporal dementia (FTD), particularly those with behavioral variant social and executive deficits (bvFTD). Standardized behavioral inventory was employed to survey and compare apathy ratings from patients and caregivers. In cases of bvFTD, apathy ratings were further related to measures of social cognition, executive function, and atrophy on brain MRI. Results indicated that caregivers rated bvFTD patients as having significantly elevated apathy scores though patient self-ratings were normal. Caregiver and self-ratings of FTD samples with progressive nonfluent aphasia and semantic dementia did not differ from healthy controls and their informants. In the bvFTD sample. caregiver apathy scores were not correlated with general cognitive screening or depression scores, but were significantly correlated with social cognition and executive function measures. Voxel-based morphometry revealed that apathy ratings in bvFFD were related to prominent atrophy in the right caudate (including the ventral striatum), the right temporo-parietal junction, right posterior inferior and middle temporal gyri, and left frontal operculum- anterior insula region. Findings suggest that bvFTD is associated with a significant breakdown in goal-directed motivated behavior involving disruption of cortical-basal ganglia circuits that is also related to social and executive function deficits.