Clinical characteristics indicating adenomyosis coexisting with leiomyomas: a retrospective, questionnaire-based study
Clinical characteristics indicating adenomyosis coexisting with leiomyomas: a retrospective, questionnaire-based study
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DOI：
10.1016/j.fertnstert.2013.09.038
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发表时间：
2014-01-01
影响因子：
6.7
通讯作者：
Taran, Florin A.
中科院分区：
文献类型：
--
作者：
Brucker, Sara Y.;Huebner, Markus;Taran, Florin A.
目的：探讨女性平滑肌瘤伴发子宫腺肌症的临床特点。设计：回顾性问卷研究。环境：学术医疗中心。患者：研究样本共包括560名女性：159名患有子宫腺肌症和平滑肌瘤的女性和401名单独患有平滑肌瘤的女性。干预措施：邮寄症状问卷。主要结局指标：子宫切除术合并子宫腺肌症和平滑肌瘤的妇女与单纯平滑肌瘤妇女的比较。结果：合并诊断为子宫腺肌症和平滑肌瘤的女性在手术前月经期间的疾病负担评分明显更高：大量出血发作和血栓通过。此外，患有子宫腺肌症和平滑肌瘤的女性在月经期间和与月经周期无关的盆腔疼痛方面报告的痛苦评分更高。此外，在多变量分析中，年龄较大（比值比[OR] 1.10, 95%可信区间[CI] 1.04-1.18）、妊娠（比值比[OR] 1.44, 95% CI 1.12-1.74）和月经期间发生盆腔疼痛（比值比[OR] 1.27, 95% CI 1.06-1.54）增加了患子宫腺肌症的几率，而不仅仅是平滑肌瘤。结论：子宫腺肌症对女性合并子宫腺肌症和平滑肌瘤的症状有影响。肥料(R) 2014；101: 237 - 41。(C) 2014年由美国生殖医学学会发布。)
Objective: To elucidate the clinical profile of a concomitant diagnosis of adenomyosis in women with leiomyomas.Design: Retrospective questionnaire-based study.Setting: Academic medical center.Patient(s): The study sample comprised a total of 560 women: 159 women with adenomyosis and leiomyomas and 401 women with leiomyomas alone.Intervention(s): Mailing of a symptom questionnaire.Main Outcome Measure(s): Comparison of women undergoing hysterectomy with adenomyosis and leiomyomas and women with leiomyomas alone.Result(s): Women with a concomitant diagnosis of adenomyosis and leiomyomas had significantly higher scores for disease burden during the menstrual period before surgery: heavy bleeding episodes and passing blood clots. Furthermore, women with adenomyosis and leiomyomas reported higher scores of distress regarding pelvic pain occurring during the menstrual period and pelvic pain not associated with the menstrual cycle. Moreover, in multivariate analysis, older age (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04-1.18), gravidity (OR 1.44, 95% CI 1.12-1.74), and pelvic pain occurring during the menstrual period (OR 1.27, 95% CI 1.06-1.54) increase the odds of having adenomyosis and not only leiomyomas.Conclusion(s): Adenomyosis contributes to symptomatology in women with concomitant adenomyosis and leiomyomas. (Fertil Steril (R) 2014; 101: 237-41. (C) 2014 by American Society for Reproductive Medicine.)