[RhCp*Cl2]2-Catalyzed Directed N-Boc Amidation of Arenes "on Water"
[RhCp*Cl2]2-Catalyzed Directed N-Boc Amidation of Arenes "on Water"
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[RhCpCl-2](2)-催化芳烃“水上”定向 N-Boc 酰胺化
DOI：
10.1021/acs.orglett.5b00392
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发表时间：
2015-03-20
期刊：
影响因子：
5.2
通讯作者：
Lu, Hongjian
中科院分区：
文献类型：
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作者：
Ali, Md Ashif;Yao, Xiayin;Lu, Hongjian
铑（III）在水中的催化作用对芳烃的C-H直接酰胺化反应是有效的。的催化过程是促进由OH基团存在于疏水性的水表面上，是低效的，在所有（大多数）常见的有机溶剂研究到目前为止。在易于制备的2，4-二硝基苯氧基氨基甲酸叔丁酯（一种新的且稳定的氮烯源）存在下，水上反应可以有效地提供所需的具有良好官能团耐受性的N-Boc胺化产物。
Rhodium(III) catalysis on water is effective for directed C-H amidation of arenes. The catalytic process is promoted by OH groups present on the hydrophobic water surface and is inefficient in all (most) common organic solvents investigated so far. In the presence of easily prepared tert-butyl 2,4-dinitrophenoxycarbamate, a new and stable nitrene source, the on water reaction can efficiently provide the desired N-Boc-aminated products with good functional group tolerance.