Stochastic particle formulation of the vesicle hypothesis. Relevance to short-term phenomena
Stochastic particle formulation of the vesicle hypothesis. Relevance to short-term phenomena
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DOI：
10.1097/00001756-199603220-00022
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发表时间：
1996-03-22
期刊：
影响因子：
1.7
通讯作者：
Kostopoulos, GK
中科院分区：
文献类型：
--
作者：
Melkonian, DS;Kostopoulos, GK
基于囊泡假说，基本量子囊泡相互作用的模式已制定的诱导和自发态间量子跃迁的概率，并在先前开发的双屏障突触理论的框架内推广。在量子的三种允许态中，过渡态是一种新的表述，它描述了由囊泡和突触前膜控制的立即可用的量子的部分。模型参数的确定通过拟合的解决方案，以实验曲线表示的影响，单脉冲和短序列激活在青蛙神经肌肉接头的递质释放。一方面，在低量子输出下发现的发射器释放的粒子物理学性质的差异，另一方面，正常传输允许制定的不确定性假设和突触稳态的量子条件。
BASED on the vesicle hypothesis, the modes of elementary quantum-vesicle interactions have been formulated in terms of probabilities of induced and spontaneous interstate quanta transitions and generalized within the framework of the previously developed theory of the double barrier synapse. Among the three allowed states for a quantum, the transition state is a novel formulation for the fraction of immediately available quanta governed by both vesicle and presynaptic membranes. The parameters of the model were determined by fitting solutions to the experimental curves representing effects of single pulse and short train activation on transmitter release at the frog neuromuscular junction. Qualitative differences in particle physics of transmitter release found under low quantal outputs on one hand and normal transmission on the other allowed the formulation of the uncertainty hypothesis and the quantum condition of synaptic homeostasis.