Blood pressure and heart rate development in young spontaneously hypertensive rats
Blood pressure and heart rate development in young spontaneously hypertensive rats
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DOI：
10.1152/ajpheart.1998.274.3.h794
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发表时间：
1998-03-01
影响因子：
4.8
通讯作者：
Lee, RMKW
中科院分区：
文献类型：
--
作者：
Dickhout, JG;Lee, RMKW
本实验通过测定2、3、4、6周龄自发性高血压大鼠（SHR）的收缩压（BP）、体重和心率（KR）的变化，研究了SHR高血压的发展过程。为了实现这一目标，我们比较了SHR和Wistar-Kyoto大鼠（WKY）的近交系，以确定同一品系的近交系之间或品系之间是否存在BP、体重或HR的差异。然后评估这些差异对血压最终水平的影响。我们发现SHR和WKY的血压在4周龄时开始出现差异。4周龄时SHR近交系之间收缩压（24 mmHg）的显著差异不影响8周龄时的血压（172与170 mmHg）。在4周龄时，SHR的脉压显著高于WKY。3周龄时SHR的HR高于年龄匹配的WKY，且与6周龄时个体动物获得的BP水平呈正相关（P = 0.037）。此外，显示HR升高的WKY近交系在10-12周龄和20周龄时产生了较高的BP（145与127 mmHg）。高血压前期心动过速在SHR进行了进一步的研究，发现从增加的内在HR. Because HR在3周是一个遗传性状，可以划分到近交系，和近交系最表达这一特点表现出最高的最终BP，我们得出结论，高血压前期心动过速可能是一个重要的第一步，在高血压的发展过程中，在SHR。此外，在研究的动物群体中，HR的早期升高高度预测（r = 0.41）高血压的发生。
The course of hypertension development in young spontaneously hypertensive rats (SHR) was studied by the measurement of changes in systolic blood pressure (BP), body weight, and heart rate (KR) at 2, 3, 4, and 6 wk of age. To achieve this, we compared inbreeding lines of SHR and Wistar-Kyoto rats (WKY) to determine if differences in BP, body weight, or HR were present among inbreeding lines of the same strain or between strains. The effect of these differences on the eventual level of BP was then assessed. We found that BP began to diverge between SHR and WKY at 4 wk of age. Significant differences in systolic BP (24 mmHg) between SHR inbreeding lines at 4 wk of age did not affect the BP at 8 wk (172 vs. 170 mmHg). Pulse pressure was significantly higher in SHR than in WKY at 4 wk of age. HR was elevated in SHR over age-matched WKY at 3 wk of age and positively correlated to the level of BP attained by individual animals at 6 wk (P = 0.037). Moreover, WKY inbreeding lines showing elevated HR developed higher BP (145 vs. 127 mmHg) at 10-12 and 20 wk of age. The prehypertensive tachycardia in SHR was investigated further and found to result from an increased intrinsic HR. Because HR at 3 wk is a genetic trait that can be partitioned into inbreeding lines, and inbreeding lines most expressive of this trait showed the highest eventual BP, we conclude that prehypertensive tachycardia may be an important first step during hypertension development in SHR. Moreover, early elevations in HR are highly predictive (r = 0.41) of hypertension occurrence in the animal population studied.