Comparative efficacy of insect repellents against mosquito bites
Comparative efficacy of insect repellents against mosquito bites
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DOI：
10.1056/nejmoa011699
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发表时间：
2002-07-04
影响因子：
158.5
通讯作者：
Day, JF
中科院分区：
文献类型：
--
作者：
Fradin, MS;Day, JF
背景资料：节肢动物传播的疾病及其相关的发病率和死亡率的全球威胁，强调了对有效驱虫剂的需求。向消费者推销多种化学、植物和"替代“驱蚊产品。我们试图确定哪些产品在美国提供可靠和长期的完整保护，从蚊子叮咬。方法：我们进行了研究，涉及15名志愿者，以测试7种植物驱虫剂的相对功效;四种产品含有N，N-二乙基-间甲苯酰胺，现在称为N，N-二乙基-3-甲基苯甲酰胺（DEET）;一种驱虫剂含有IR 3535（乙基丁基乙酰氨基丙酸酯）;三个驱虫浸渍腕带;和保湿剂，通常声称具有驱蚊效果。这些产品进行了测试，在一个受控的实验室环境中，蚊子的种类，他们的年龄，他们的饥饿程度，湿度，温度，和光暗周期都保持constant.Results：避蚊胺为基础的产品提供了最长的时间完整的保护。高浓度的避蚊胺提供更持久的保护。含有23.8%避蚊胺的配方平均完全保护时间为301.5分钟。一种以大豆油为基础的驱蚊剂平均可以防止蚊子叮咬94.6分钟。基于IR 3535的驱避剂的平均保护时间为22.9分钟。我们测试的所有其他植物驱避剂提供的保护平均持续时间不到20分钟。驱避剂浸渍的腕带提供了没有protection.Conclusions：目前可用的非避蚊胺驱蚊剂不提供保护的持续时间类似于基于避蚊胺的驱蚊剂，不能依赖于提供长期的保护环境中，蚊媒疾病是一个重大的威胁。（新英格兰医学杂志2002;347：13-8。）
Background: The worldwide threat of arthropod-transmitted diseases, with their associated morbidity and mortality, underscores the need for effective insect repellents. Multiple chemical, botanical, and ``alternative'' repellent products are marketed to consumers. We sought to determine which products available in the United States provide reliable and prolonged complete protection from mosquito bites.Methods: We conducted studies involving 15 volunteers to test the relative efficacy of seven botanical insect repellents; four products containing N,N-diethyl-m-toluamide, now called N,N-diethyl-3-methylbenzamide (DEET); a repellent containing IR3535 (ethyl butylacetylaminopropionate); three repellent-impregnated wristbands; and a moisturizer that is commonly claimed to have repellent effects. These products were tested in a controlled laboratory environment in which the species of the mosquitoes, their age, their degree of hunger, the humidity, the temperature, and the light-dark cycle were all kept constant.Results: DEET-based products provided complete protection for the longest duration. Higher concentrations of DEET provided longer-lasting protection. A formulation containing 23.8 percent DEET had a mean complete-protection time of 301.5 minutes. A soybean-oil-based repellent protected against mosquito bites for an average of 94.6 minutes. The IR3535-based repellent protected for an average of 22.9 minutes. All other botanical repellents we tested provided protection for a mean duration of less than 20 minutes. Repellent-impregnated wristbands offered no protection.Conclusions: Currently available non-DEET repellents do not provide protection for durations similar to those of DEET-based repellents and cannot be relied on to provide prolonged protection in environments where mosquito-borne diseases are a substantial threat. (N Engl J Med 2002;347:13-8.)