Birth weight and body composition in young women: a prospective twin study
Birth weight and body composition in young women: a prospective twin study
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DOI：
10.1093/ajcn/75.4.676
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发表时间：
2002-04-01
影响因子：
7.1
通讯作者：
Vlietinck, R
中科院分区：
文献类型：
--
作者：
Loos, RJF;Beunen, G;Vlietinck, R
背景：宫内环境可能是肥胖发生的关键。或者，同样的遗传因素可能同时影响出生体重和成人身体组成。目的：我们评估了女性双胞胎出生体重和成年身体组成之间的关联，这使得我们能够控制母体和遗传的影响。设计：从东佛兰德斯双胞胎前瞻性调查中随机选择447对双胞胎，238对年龄在18-34岁之间。测量成人体重、身高和瘦体质量，计算体重指数(BMI)、腰臀比和皮褶厚度总和。结果：当双胞胎被视为个体时，出生时较重的双胞胎成年后身高(比出生体重高3.3 cm/kg)和稍重(比出生体重高1.13 kg/kg)。他们出生时也有更多的瘦体重，更少的皮下脂肪和腹部脂肪。两两比较表明，对于每一水平的双胞胎出生体重差异(大于或等于5%，大于或等于10%，以及大于或等于15%)，出生时较重的双胞胎成年后身高(分别为0.8、1.2和2.0厘米)。当双胞胎内出生体重差异超过15%时，双胞胎中体重较大的成年后体重(3.1+/-6.08 kg)也比较轻的姐姐重(3.1+/-6.08 kg)。结论：出生体重是双胞胎成人体成分差异的部分原因。
Background: The intrauterine environment may be critical for the development of obesity. Alternatively, the same genetic factors may influence both birth weight and adult body composition.Objective: We evaluated the association between birth weight and adult body composition in female twins, which allowed us to control for maternal and genetic influences. Design: Of 447 twin pairs randomly selected from the East Flanders Prospective Twin Survey, 238 pairs, aged 18-34 y, participated. Adult body mass, height, and lean body mass were measured, and the body mass index (BMI), waist-to-hip ratio, and sum of skinfold thicknesses were calculated. The twins were considered as individuals and pairs.Results: When the twins were considered as individuals, twins who were heavier at birth were taller (3.3 cm/kg greater birth weight) and slightly heavier (1.13 kg/kg greater birth weight) as adults than were lighter twins. They also had more lean body mass and less subcutaneous and abdominal fat at birth. Pairwise comparison showed that for every level of intrapair birth weight difference (greater than or equal to5%, greater than or equal to 10%, and greater than or equal to 15%), the twin who was heavier at birth was taller in adult life (0.8, 1.2, and 2.0 cm, respectively). When the intrapair birth weight difference exceeded 15%, the heavier twin was also heavier (3.1+/-6.08 kg) as an adult than her much lighter sister.Conclusion: Birth weight accounts for some of the differences in adult body composition between twins.