2D MOF Periodontitis Photodynamic Ion Therapy
2D MOF Periodontitis Photodynamic Ion Therapy
复制标题
2D MOF 牙周炎光动力离子治疗
DOI：
10.1021/jacs.1c07875
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发表时间：
2021-09-13
影响因子：
15
通讯作者：
Wu, Shuilin
中科院分区：
文献类型：
--
作者：
Li, Jun;Song, Shuang;Wu, Shuilin
传统的外科手术和抗生素治疗对包括牙周炎在内的各种口腔病原体引起的慢性疾病效果不佳甚至无效，常导致组织的进行性破坏，甚至牙齿脱落和全身性疾病。本文中，通过掺入聚乙二醇基质来设计包含原子层Fe 2 O3改性的二维卟啉金属有机骨架（2D MOF）纳米片的软膏。原子层沉积表面工程后，增强的光催化活性的2D MOF异质界面的结果从较低的吸附能和更多的电荷转移量由于金属连接剂桥接单元，丰富的活性位点的协同效应，和一个优秀的捕光网络。这种生物相容性和可生物降解的基于2D MOF的异质结构通过活性氧和释放的离子的协同作用对多种口腔病原体（牙龈卟啉单胞菌、具核梭杆菌和金黄色葡萄球菌）表现出广谱抗微生物活性（99.87 +/-0.09%、99.57 +/-0.21%和99.03 +/- 0.24%）。这种光动力离子疗法由于快速的抗菌活性、减轻炎症和改善血管生成而表现出优于已报道的临床牙周炎治疗的治疗效果。
Traditional surgical intervention and antibiotic treatment are poor and even invalid for chronic diseases including periodontitis induced by diverse oral pathogens, which often causes progressive destruction of tissues, even tooth loss, and systemic diseases. Herein, an ointment comprising atomic-layer Fe2O3-modified two-dimensional porphyrinic metal-organic framework (2D MOF) nanosheets is designed by incorporating a polyethylene glycol matrix. After the atomic layer deposition surface engineering, the enhanced photocatalytic activity of the 2D MOF heterointerface results from lower adsorption energy and more charge transfer amounts due to the synergistic effect of metal-linker bridging units, abundant active sites, and an excellent light-harvesting network. This biocompatible and biodegradable 2D MOF-based heterostructure exhibits broad-spectrum antimicrobial activity (99.87 +/- 0.09%, 99.57 +/- 0.21%, and 99.03 +/- 0.24%) against diverse oral pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, and Staphylococcus aureus) by the synergistic effect of reactive oxygen species and released ions. This photodynamic ion therapy exhibits a superior therapeutic effect to the reported clinical periodontitis treatment owing to rapid antibacterial activity, alleviative inflammation, and improved angiogenesis.