On the Relationship between MRI and Local Field Potential Measurements of Spatial and Temporal Variations in Functional Connectivity
On the Relationship between MRI and Local Field Potential Measurements of Spatial and Temporal Variations in Functional Connectivity
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DOI：
10.1038/s41598-019-45404-8
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发表时间：
2019-06-20
影响因子：
4.6
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Shi, Zhaoyue;Wilkes, Don M.;Gore, John C.
静息状态BOLD fMRI信号波动之间的相关性被解释为功能连接（FC）的措施，但其起源的神经基础及其与潜在电生理活动的具体特征的关系，尚未完全建立。特别是，FC指标对不同频带的局部场电位（LFP）的依赖性，以及BOLD FC的动态变化与LFP相关性的潜在时间变化的关系，是未知的。我们比较了LFP信号的不同频带的静息状态相干性的空间分布，具有高分辨率的静息状态BOLD FC测量。我们还比较了概率分布的时间变化的连接在这两种方式使用马尔可夫链模型为基础的方法。我们分析了从猴子的初级体感（S1）皮层获得的数据。我们发现，在S1皮层的3b区和1区，低频LFP信号波动是静息状态LFP相干性的主要贡献。此外，BOLD FC的动态变化表现得与LFP低频信号相干性最相似。这些结果表明，在所研究的S1皮层中尺度回路中，BOLD fMRI的静息状态FC测量主要反映低频LFP信号及其动态变化的贡献。
Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence of FC metrics on different frequency bands of local field potentials (LFPs), and the relationship of dynamic changes in BOLD FC to underlying temporal variations of LFP correlations, are not known. We compared the spatial profiles of resting state coherences of different frequency bands of LFP signals, with high resolution resting state BOLD FC measurements. We also compared the probability distributions of temporal variations of connectivity in both modalities using a Markov chain model-based approach. We analyzed data obtained from the primary somatosensory (S1) cortex of monkeys. We found that in areas 3b and 1 of S1 cortex, low frequency LFP signal fluctuations were the main contributions to resting state LFP coherence. Additionally, the dynamic changes of BOLD FC behaved most similarly to the LFP low frequency signal coherence. These results indicate that, within the S1 cortex meso-scale circuit studied, resting state FC measures from BOLD fMRI mainly reflect contributions from low frequency LFP signals and their dynamic changes.